Paper claims Tigercycline is 100's of times more effective at killing borrelia than Doxy

...and also kills round body/persister cell forms at low concentrations

"The MBC of doxycycline, one of the recommended antibiotics used for effective early treatment of Lyme borreliosis for this strain of Borrelia burgdorferi, was 8 μL/mL for the spirochete morphotype and a concentration thirty-two times higher (256 μL/mL) for the much more resistant RB forms. TG is here far more effective than doxycycline in destruction of the Borrelia RB propagules. "

"Spirochetes exposed to TG concentrations >0.006 μg/mL for 7 d had disintegrated; only a few empty membrane bounded RBs were present."

full paper here https://www.pnas.org/doi/full/10.1073/pnas.0908236106

makes you wonder why this abx is not used more often - did i read somewhere that it was a possible mutagen ?

trkane said...
I had this with IV (dr j). It was toward the end of the protocol. They called it the tiger. It was yellow.

By then I was so wiped out from everything. It was rough

thanks for the input - i rarely hear about it being used - perhaps because it is an IV only option

did you find you benefited from the protocol overall / reach remission ?

That it would wipe someone out with the effectiveness it is said to have is not surprising. With IVIG, you can throw “slow as you go” out the window.

I found that out 10 years ago with Rocephin. Horrendous reaction. Too much too quick, so we changed to Bicillin and it worked.

Sorry. Lactate ringers

https://www.mayoclinic.org/drugs-supplements/lactated-ringers-intravenous-route/description/drg-20489612

He runs them for detox. Every other day and weekend. I left my port in an extra month just to run these.

“ I don't remember having the "blue sky thing". For me it was a very gradual getting my life back. “

Me too - even after I finished the protocols - and went on to “maintenance “ I continued to improve….just more subtly.