Found this old paper on pH values and Borrelia's surface protein expressions.
It is fascinating how pH plays role in chronic Lyme disease of constant relapses.
https://www.ncbi.nlm.nih.gov/pmc/articles/pmc116493/This Paper says said...
When B. burgdorferi B31 was incubated at pH 8.0, the alterations in the 2D-NEPHGE immunogenic protein profile were much more striking. Several protein spots were undetectable. Protein spots I-3, I-5, I-7, I-8, I-9, I-10, I-16, I-17, I-18, I-20, I-23, I-25, I-26, and I-31, all present in samples at pH 7.0, were undetectable in samples at pH 8.0 (Fig. (Fig.3).3). In addition, numerous spots appeared to decrease in amount, including I-2, I-19, I-22, I-24, I-28, I-29, I-32, I-33, and OspC. At pH 8.0 spots I-1, I-12, I-15, and I-21 increased, with spot I-11 being specific for pH 8.0 (Fig. (Fig.33).
Borrelia's 37 surface proteins are expressed differently in different environments. It survives mostly in alkaline environments between 7pH to 8pH. Just a difference of 1 pH from 7 pH to 8 pH changes the surface proteins expressed by the bacteria to adapt to the environment.
Bones and collagen are of pH ~7.4! Makes sense why Borrelia like to live in bones, collagen, joints and bladder, places where pH is from 7 to 8!
https://www.ncbi.nlm.nih.gov/pmc/articles/pmc5946302/#:~:text=conversely%2c%20osteoblasts%2c%20the%20bone%20cells,7.0%20and%207.2%20%5b23%5d.This paper said...
Conversely, osteoblasts, the bone cells that deposit new bone, work best at a pH of 7.4 and in a more acid environment will not mineralize bone collagen matrix. Interstitial tissue pH has been measured between 7.0 and 7.2 [23]
This explains so much of what is going on in chronic Lyme disease, lab tests, and relapses.
Most chronically stressed people have alkaline bodies; stress and cortisol increase their bodies' pH, making them more alkaline. Their body temperatures are low, their thyroid is less effective, and they mostly have sluggish body chemistry, from low response to nutrition to low hormones, and neurotransmitters.
No wonder why there is a relationship between more psychologically stressed people acquiring Lyme, especially when they go through trauma, and intense stress. Physically and emotionally healthy people with no stress are more resistant to Borrelia/Lyme.
Makes sense why some people achieve remission by making just lifestyle changes, the right foods, removing stress, and psychological changes and healing/meditation, bringing body pH balance back, and making it easy to get rid of Borrelia.
If the pH is varying then borrelia's surface protein is changing, which tells why the western blot and other Lyme tests don't detect the proteins consistently. Makes sense why the Lyme test is not effective. The bands are a trouble to detect. If pH is maintained correctly before the test, then tests may give more accurate results.
Since the surface proteins are expressed differently in different body pH, can cause the immune to be less effective in producing antibodies and identifying the pathogen. Immune can't do its job. Borrelia is using this as his decoy to evade immunity.
So pH needs to be tweaked for making the body less conducive for borrelia, then Borrelia will form less biofilm, it is forced to stay in spirochetes form, then antibiotics can work better since borrelia will mostly stay in the spirochetes form. It can't hide. Then treatments will actually work.
Basically, pH is what Borrelia uses to make its decisions! This seems to be the key to preparing the perfect protocol.
Makes sense why some natural compounds help kill Borrelia, like grapefruit seed extract, GSE has pH 2.90 pH, acidic, and helps the body to balance its pH! Pomegranates has pH of ~3. ACV. has pH of ~3.
This publication has a list of foods for food therapy for Lyme. Most of them are of pH from 3 to 6! Changing food towards more acidic can shift the balance!
https://www.pacificcollege.edu/news/blog/2021/02/03/report-of-findings-of-a-clinical-case-on-lyme-diseasewww.pacificcollege.edu said...
Food therapy would be discussed, as well as, supplement suggestions for S.M. She is advised to avoid the following: chicken, duck, fish, and shrimp, and all forms of sugar, honey, jujube dates, and other sweet substances. This is discussed in Chinese texts including Zhigu Xinfang (New Approaches to Gu Therapy) from 1823, in which the patient is advised to increase amounts of the following: tofu, celery, cabbage, spinach, lotus root, shiso (perilla) leaves, peppermint, garlic, horseradish, ginger, bitter melon, black mu’er fungus, lychee, longan, oranges, tangerines, grapefruit, plums, pomegranates, watermelon, vinegar and green tea (Quinn, 2016). However, if any of these items should further aggravate the condition, it should also be avoided. Supplement suggestions for this patient would include: 5HTP, CBD, magnesium glycinate, vitamin B6 and vitamin B12.
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Post Edited (newuser22) : 10/16/2023 12:13:08 AM (GMT-8)