Ivermectin Info

ChristianWithLyme said...

"In addition to its wide-spectrum antiviral activity, Ivermectin is a remarkably good macrolide antibiotic. It even kills some antibiotic-resistant strains of Mycobacterium tuberculosis. A very useful drug indeed!"

Hi. So you're saying that the anthelminthic drug ivermectin is also part of the macrolide group of antibiotics such as Azithromycin?
Does this mean that ivermectin also comes with a black box warning due to potential fatal arrhythmia side effects?

I didnt know marcoliuds were black box.

There is a ton of differences between azithro and iver, for one thing azithro works within macrophages and macrophages suck in this abx to later deploy it in inflammation sites. There is no info like this for ivermectin.

Azithro is distributed in brain tissue https://www.ncbi.nlm.nih.gov/pmc/articles/PMC163212/
Iver is probably not.

> also comes with a black box warning due to potential fatal arrhythmia side effects

herx - reduce the dose

Post Edited (Dmitry) : 8/8/2020 5:27:18 PM (GMT-6)

@ChristianWithLyme are you on olmesartan?

WalkingbyFaith said...
Interesting. Thanks for sharing this. My doctor prescribed Ivermectin, but I haven’t been able to get it. The pharmacy just said the manufacture isn’t making it right now???

Anybody know how I can get it?

I came across it a while ago - people on other forums were buying it from veterinary suppliers in tubes and taking it that way ( for chickens or hrse etc i think)
I'm not recommending that - but i don't recall anything bad happening to any of them!

i think the issue with the supply in the western world is to do with pharmaceutical companies superseding it with newer probably more expensive drugs
its still used widely outside north America and western europe
if you try one of teh better international pharmacies i am sure they will have it
made for humans and of suitable quality

this thread discusses well used and trusted online sources of many ABX etc
(i have used several and they were fine for me)
https://forums.phoenixrising.me/threads/tips-for-finding-reliable-and-trustworthy-prescription-free-online-pharmacies.8113/

Somebody said...


A Combination of Ivermectin and Doxycycline Possibly Blocks the Viral Entry and Modulate the Innate Immune Response in COVID-19 Patients

Preprint submitted on 09.07.2020, 05:29 and posted on 09.07.2020, 08:22 by Dharmendra Kumar Maurya

The current outbreak of the corona virus disease 2019 (COVID-19), has affected almost entire world and become pandemic now. Currently, there is neither any FDA approved drugs nor any vaccines available to control it. Very recently in Bangladesh, a group of doctors reported astounding success in treating patients suffering from COVID-19 with two commonly used drugs, Ivermectin and Doxycycline. In the current study we have explored the possible mechanism by which these drugs might have worked for the positive response in the COVID-19 patients. To explore the mechanism we have used molecular docking and molecular dynamics simulation approach.

Effectiveness of Ivermectin and doxycycline were evaluated against Main Protease (Mpro), Spike (S) protein, Nucleocapsid (N), RNA-dependent RNA polymerase (RdRp, NSP12), ADP Ribose Phosphatase (NSP3), Endoribonuclease (NSP15) and methyltransferase (NSP10-NSP16 complex) of SARS-CoV-2 as well as human angiotensin converting enzyme 2 (ACE2) receptor. Our study shows that both Ivermectin and doxycycline have significantly bind with SARS-CoV-2 proteins but Ivermectin was better binding than doxycycline. Ivermectin showed a perfect binding site to the Spike-RBD and ACE2 interacting region indicating that it might be interfering in the interaction of spike with ACE2 and preventing the viral entry in to the host cells. Ivermectin also exhibited significant binding affinity with different SARS-CoV-2 structural and non-structural proteins (NSPs) which have diverse functions in virus life cycle.

Significant binding of Ivermectin with RdRp indicate its role in the inhibition of the viral replication and ultimately impeding the multiplication of the virus. Ivermectin also possess significant binding affinity with NSP3, NSP10, NSP15 and NSP16 which helps virus in escaping from host immune system. Molecular dynamics simulation study shows that binding of the Ivermectin with Mpro, Spike, NSP3, NSP16 and ACE2 was quiet stable.

Thus, our docking and simulation studies reveal that combination of Ivermectin and doxycycline might be executing the effect by inhibition of viral entry and enhance viral load clearance by targeting various viral functional proteins.

ChristianWithLyme said...

Dmitry said...
@ChristianWithLyme are you on olmesartan?
No, why do you ask?
it.

Because Marshall is typically associated with it.

The interesting thing to me about HCQ is that the half-life is 22 days. I never understood how it could work immediately if the half-life is 22 days and it takes months to work for everything else. Maybe this is why the trials fail, but there seems to be some protective benefit in the numbers based on countries that use it prophetically for malaria.

But Ivermectin is another anti-parasitic, but w/ a half-life of only 18hrs. Could work quickly, may be something to this.

Dmitry said...

ChristianWithLyme said...

Dmitry said...
@ChristianWithLyme are you on olmesartan?
No, why do you ask?
it.

Because Marshall is typically associated with it.

////////////////////////

You’re referring to the Marshall protocol?
(Sun avoidance and taking Olmesartan)

this guy - Dr Mobeen - has a youtube channel and website - the same guy that interviewed Dr Phillips in the other thread.

i find him quirky but well qualified and open-minded and has presented quite a lot of information on the mechanisms of action of ivermectin in SARS-Cov-2 infection and also in Covid long haulers.
many of these mechanisms are relevant to our discussions around auto-immunity and stuck immune dysregulation in chronic lyme - or potentially even a cause for chronic lyme.

he quotes his sources and once you are past his presenting style is actually pretty rational and astute.

eg
https://www.youtube.com/watch?v=JEO7Adv3tVI

in his interview, Dr Phillips talks about using Ivermectin for Chronic Lyme for its immune-modulating effects with some remarkable results.

drs up north are doing 12-18 mg per day for 6-8 weeks for long haulers . energy usually comes back after 3 or 4 but must keep on it ....

that is the c-19 dosing from dr c ...babesia needs to be treated for at least 120 days as infected cells reach apotopsis. usually treated with artminsin or other anti malarials . alinia is effective against both and is tolerable after intial herxes.