Here's an interesting article I archived and came across today while looking for something else.
The article is from an interview with Tim Jackson... here's the link followed by the critical info on IgG vs IgM in chronic illness.
https://selfhacked.com/2015/10/13/tim-jackson-leader-in-alternative-medicine-addressing-the-root-cause-of-chronic-illness-lyme-mold-and-other-pathogen-related-health-problems/
Following text is copied from the article linked above
Q: What do you think the underlying cause of chronic fatigue is?
A: The allopathic model has us thinking regarding simple cause and effect, but in the functional medicine matrix there are usually 10 or 12 different systems interacting to create this problem. For instance, a lot of people think if you heal the gut you’ll heal everything. True much of the time, but you can have systemic inflammation or systemic immune imbalance that leads to leaky gut so regarding chronic fatigue you see a conglomeration of symptoms. Normally there are some pathogens like HHV6, Mycoplasma (a cell wall deficient bacteria), Epstein-Barr. One thing to emphasize-even in the integrative circles they have been taught wrongly and incorrectly believe that IGM means that it’s a current infection, and IGG means a past infection (from college, or from childhood)- but in the work of Alex Vasquez (who wrote the book, “Integrative Rheumatology,”), there is discussion about
some people not being able to mount an IGM response– their only immune attack is IGG. Therefore, if IGG levels are 3-4X the top of the normal range, this signifies currently active virus. As these numbers fall, even IGG numbers, people feel better. So Tim thinks there’s definitely a pathogen component, and a neuroinflammatory component, (often coming from the pathogens). So the microglial cells which we used to think were just structural in the brain and central nervous system play the role of an immune cell. When they get turned on they create brain fog, moodiness, insomnia, fatigue. There’s a number of different pathogens that can turn them on. Lipopolysaccharides from gram-negative bacteria (bad bacteria in the gut) can turn your microglia on, so that’s where the concept comes from that if you have a leaky gut eventually you’re going to have a leaky blood brain barrier.
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IGG
A: There’s a handful of studies that show this (that IGG does not equate to past infections, but can signify a current infection). More importantly, Alex Vasquez (mentor he mentioned prior) who holds three doctorates, a DO, an MD and a Chiropractor, and published over a hundred different articles, wrote the textbook on it. He’s seen that clinically. Also, doctor Jacob Teitelbaum who wrote: “From Fatigued to Fantastic.” There are a handful of studies that show that. But more importantly we need to get out of this mindset of evidence-based medicine which even the British medical journal declares is an epic failure because they cherry pick their evidence and this hyper-specialization of only looking at one area of the body is detrimental to all of us. He’s very thankful for conventional medicine for things like kidney stones, broken arm, etc. but outside of that their model of saying there’s no studies for this or that, 95% of the time there are studies you just aren’t finding them. For example, you mentioned leaky gut, if you type in the leaky gut on PubMed it’s going to bring up nothing. But if you type in gut hyper-permeability it will bring up a lot of things. So there’s plenty of research that supports it. Most medical text books are sponsored in part by Pfizer or Merck. You’re getting cause information. Take depression for example, we know it’s a neuro-inflammatory condition, we know there are cytokines involved.
Q: What about
high IGG-what range do you see somebody has chronic infections? I haven’t read many studies on IGG, but I wouldn’t be surprised if high IGG would signify viral infections. But what ranges do you see where you would say “ok it’s over this, so this person has systemic viral infections.”
A: I look at the normal range, taking into consideration that the range was from sick people, so it’s somewhat skewed or sometimes very skewed, but if the IGG number is 3X the normal range or 4X the normal range or 10 or 12 times the normal range, that’s a currently active infection. He tries to get people out of this-it’s great if we have a study for it, but clinically this is what he sees happen over and over again without fail. Learned from two very valuable sources-Dr. Vasquez and Dr. Teitelbaum, very reputable sources. Because of their clinical experiences with many patients a day with these sorts of symptoms, they’re going to be far ahead from what the research shows. It’s great to have a mechanism and a study and double blind placebo controlled studies on all of that, but it’s so easy to manipulate those; a lot of times people only publish good results and not the bad ones. For statin drugs look at all the studies showing that they cause mitochondrial damage, they predispose you to diabetes. Cholesterol isn’t even the issue; it’s more inflammation and the percent oxidized cholesterol. If you want to focus on anything with cholesterol—look at the percent oxidized LDL, LPA, APOB. Look at those factors and not the total cholesterol, because up until the 1980s or so, Hypocholesterolemia was indicative of subclinical hypothyroidism, but then all these antidepressants started coming out, and so they changed that. An MD he collaborates with said when she was at her residency, the thyroid reference ranges were very different (she’s been practicing for about
30 years, and they even vary from state to state). What he tells people when they see these normal ranges- “normal is Homer Simpson.” Waiting for all markers to be out-of-range would mean being in an intensive care unit.
Post Edited (tickbite666) : 9/22/2022 7:10:32 PM (GMT-7)