MedicalNerd said...
Interesting, I never ever knew that some anti epileptic and mood stabilizers could caise a herx.
Such antimicrobial effects have been suspected for at least two decades against toxoplasma gondii, an apicomplexan parasite somewhat distantly related to babesia:
https://pubmed.ncbi.nlm.nih.gov/12837520/Since then there has been quite a lot of research on this, often with somewhat conflicting results.
If you don't like the calm and quiet feeling, you might not like the mood stabilizers, because you might end up feeling like that all the time. I just kinda felt spaced out and didn't really want to do anything.
I haven't tried lamotrigine but I did take valproate and I got a very strong herx from it. However valproate is generally reported to have a very high antimicrobial potential compared to some of the other mood stabilizers. Of course, if you just want to kill the bugs then that might be an option for you, but be aware that the severity of the herx may overshadow any benefit on your mood.
If you don't want to use mood stabilizers, the other option is to address the endocrine issues, which can be partly due to the infections and partly due to genetics. Have you been tested for the common adrenal issues such as 21-hydroxylase deficiency and MTHFR deficiency?
The basic treatment protocol for HPA dysfunction would be low dose hydrocortisone to try to get ACTH and cortisol levels normal and rising/falling at the right time of day, and if you still get beta-endorphin effects (eg calmness) then take low dose naltrexone.
In general treating the endocrine stuff won't cause a herx, or at least it will not directly kill the bugs, but it could increase your immune response somewhat if successful.