October 2023 - Screen of 640 FDA approved drugs against B. duncani parasite growth in vitro

Maybe you should tell them you accidentally took plaquenil again and need more clemastine 😜

Haha Bailey 😂

Running wild, thank you for the kind feedback, I appreciate it!

You're very welcome carlnpa, I really hope the clemastine will help you!
I might give it a try myself.

And that's really interesting about the myelin repair!

So N=2

SMH, what is our research community doing? Rainy, you picked up this one that may actually be a better anti babesia compound than the Fosinopril that they are pushing, ranked higher in activity by their own data. It is certainly more widely distributed, and more readily available. The ancillary benefits are broad spectrum.

Very interesting compound.

Very broad action that could benefit those with tick borne disease.

The number of papers regarding beneficial use on this one is encouraging.

Rainy
I have been reading papers for hours on clemastine.

In support of the initial reference.

Systematic Analysis of Clemastine, a Candidate Apicomplexan
Parasite-Selective Tubulin-Targeting Agent

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8744746/pdf/ijms-23-00068.pdf

"Abstract: Apicomplexan parasites, such as Toxoplasma gondii, Plasmodium spp., Babesia spp., and Cryptosporidium spp., cause significant morbidity and mortality. Existing treatments are problematic due
to toxicity and the emergence of drug-resistant parasites. Because protozoan tubulin can be selectively
disrupted by small molecules to inhibit parasite growth, we assembled an in vitro testing cascade
to fully delineate effects of candidate tubulin-targeting drugs on Toxoplasma gondii and vertebrate
host cells. Using this analysis, we evaluated clemastine, an antihistamine that has been previously
shown to inhibit Plasmodium growth by competitively binding to the CCT/TRiC tubulin chaperone
as a proof-of-concept."

Edit to note.

We have access to another potent microtubule disrupter in fenbendazole.
I wonder if there may be synergy.

Post Edited (carlnpa) : 10/26/2023 3:35:16 PM (GMT-8)

Hey carlnpa, I just wanted to let you know that my clemastine arrived. I will probably give it a try tonight or tomorrow.

Quick update, I received the clemastine and have 3 days on it.

Daily recommended dosage is 1mg 2x daily.

I have taken 1/2 mg once daily (the tablet is scored so this is ok) in the evening, wierd dreams, sleeping like a log.

This is a very powerful antihistamine, I notice it in clearer sinus.

Like many things I have taken for TBD, I notice it in my eyes also. Not negatively.

Interesting stuff.

Edit

The below maybe should go over to the MS board.

Clemastine Ameliorates Myelin Deficits via Preventing Senescence of Oligodendrocytes Precursor Cells in Alzheimer’s Disease Model Mouse

https://pubmed.ncbi.nlm.nih.gov/34746130/

"Clemastine fumarate is a first-generation H1-antihistamine that is mainly used for relieving symptoms of allergic reactions primarily by competing with histamine to bind H1 receptors (Blazsó and Gábor, 1997). In addition to its anti-inflammatory effects, clemastine also shows antimuscarinic type-1 receptors effects. In recent years, it was also found clemastine, among other antimuscarinic compounds, can significantly induce oligodendrocyte precursor cell (OPC) differentiation and myelination (Mei et al., 2014), accelerating the remyelination process in animal models featured by demyelination (Mei et al., 2014, 2016; Li et al., 2015; Cree et al., 2018). Furthermore, a phase 2 clinical trial on using clemastine for treating multiple sclerosis (MS) showed that remyelination could be achieved during the chronic neurodegeneration process (Green et al., 2017). These studies collectively strongly suggest clemastine is a potent stimulator of myelin formation with a good safety profile."

Post Edited (carlnpa) : 10/27/2023 4:11:24 AM (GMT-8)

Hi carlnpa, sorry for the late reply. I hope you're doing well. Any updates?

I raised dose to 1 mg in the evening.

No adverse reactions whatsoever.

Sorry to repeat but this is a very strong antihistamine.

It has reduced the constant pain/pressure in my damaged eye. Probably an anti inflammatory effect.

Maybe a psychosomatic response but the neuropathy in my hands and feet seems lessened. Thinking pattern seems clearer.

Long covid sufferers should be looking hard at this.

Update after 3 weeks of clemastine.

Dosing 1mg in evening.

Met with my lyme LLMD today, discussed usage. He is going to check if we can get this in the US over the counter. He has TBD also so was quite interested.

MCAS responses are definitely down, eyes feel much better, acuity is better, brain fog has lessened. Neuropathy is lower.

There seems to be a pronounced synergistic response with fenbendazole.