That sounds like it could be related to anti-mag. Anti-mag kind of mimics CIDP. You predominantly think of sensory issues (numbness for example) and motor issues (ataxia, muscle weakness, tremor) combined with anti-mag. I wasn't sure if muscle atrophy could be caused by it, but was guessing yes just due to nerve involvement, and a quick google search seems to indicate yes.
I would definitely have the test re-run at a well-known lab, and an EMG is a must.
Typically with an autoimmune neuropathy, the first line treatment is going to be prednisone or plasmapheresis, but better yet IVIG. But the problem w/ anti-mag neuropathy is that unlike many other types of neuropathies caused by IgG antibodies (or sometimes T-cells), anti-mag is an IgM mediated neuropathy. IgM antibodies are secreted by plasma blasts, and circulate on the order of days to weeks. As opposed to IgG, which are secreted by plasma cells and circulate for months to years. What this means is that IVIG isn't as effective, as the antibodies are replaced quickly. Same with plex (plasmapheresis).
What is very effective against anti-mag, however, is Rituximab, as it's able to knock out the plasma blasts which secrete the IgM antibodies. This comes with both good and bad. The good news is that anti-mag tends to respond very well to Rituximab, and you may get a lot/to near total relief from your symptoms with it, and possibly go into remission. The bad side of it is that Rituximab is a much heavier duty drug than IVIG or a dose of prednisone, and comes with its own risks, particularly for someone with an infection.
The question that you'd then have to have to decide is do you actually have lyme, or just an autoimmune issue. How do you know you have lyme? Just positive tests? Clinical symptoms? A bulls-eye rash?
What part of the country are you in? Do not waste your time w/ an infectious disease specialist. I know an amazing neurologist who is the best in the business at making that lyme vs autoimmune call (he's a lyme llmd in CT but also a neurologist who treats all sorts of autoimmune neuropathies). Sometimes you have one, or the other, or both.
We may be getting ahead of ourselves here, lets see what the EMG and Quest tests say, just giving you the relevant information that you're not going to find elsewhere.
Post Edited (dcd2103) : 10/31/2021 3:07:36 PM (GMT-6)