HealingWell
Search Close Search
☰

Methylene Blue Thread

Support Forums
>
Lyme Disease
✚ New Topic ✚ Reply
❬ ❬ Previous Thread |Next Thread ❭ ❭
Posted 3/2/2024 9:26 PM (GMT 0)
I have seen a lot of talk around this lately and I have a few opinions. It is fairly well believed to be a mitochondrial function enhancer which could explain why it makes people feel better. It has also been shown to have neuroprotective effects, also potentially helpful for us.

I just started testing it for lifespan extension (I'm a Molecular biologist now) and in first trials with c. Elegans worms, it's been highly effective at extending lifespan. If I can get a few more successful trials, we can move it on to mammal testing. We're the first ones to do lifespan analysis on it so that's exciting.

What is everyone's experience with it here? I personally can't touch the stuff. One drop and I'm going insane.
Posted 3/2/2024 11:57 PM (GMT 0)
as i understand it - in low doses at essentially acts as a anti-oxidant - helping mitochondria and mopping up free radicals -

these are around the doses its often used in lyme and co - treatments - typically around 50 to 100mg per day - the same dose as has been used extensively in geriatric medicine as a mood stabiliser (many neurological age related diseases are linked to poor cellular metabolism and associated inflammation in the brain - so this is consistent with the above )

i would expect its life extension effects to occur around the same dose range and via similar mechanisms

more recent papers using methylene blue for bartonella have found its anti-persister cell effects to require much higher doses - more like 600mg per day - similar to its original dose when used for malaria ( its original antimicrobial purpose) Dr Horowitz added it to his protocols for lyme and bartonella at this dose pulsed for around 1 week - and there are people experimenting with it at these doses as a monotherapy for bartonella

i have been using it for many months now at around 120mg per day (i am 85kg - so 20% heavier than the average person used for most drug dosing )

initially combined with herbs - and later with herbs and other antibiotics - but i had to build up v slowly from around 10mg per day

Zhang and co - at johns Hopkins did some research showing it combined well with rifampicin and macrolides among other antibiotics - where its effects were synergistic against bartonella

i hope its of some help
Posted 3/3/2024 5:38 AM (GMT 0)
That's really helpful, thanks. I have tried it so many times but like I said, even 1 drop makes me go nuts. I'll be so off the wall and dissociated I can't come down for a day. I have wondered if the serotonin agonist action plays a role there.
Posted 3/4/2024 12:03 PM (GMT 0)
I tried this at a low dose and it didn't make me feel well at all!
Posted 3/4/2024 6:09 PM (GMT 0)
i had a strong reaction to it initially - had to start on a low dose - around 10mg / day and work up

the Methylene Blue for Bartonella facebook group has quite a few people on it that reacted even more strongly and could hardly tolerate a few drops of the liquid form which would probably be way lower than my 10mg starting dose

but people with bartonella in general are often very reactive to herbs, meds etc - perhaps through MCAS - or just super sensitive to Herx reactions
Posted 3/5/2024 10:25 AM (GMT 0)
Yes the MB I was taking were the drops online, I only took one drop and felt really bad! similar experience when I tried herbs for bartonella so perhaps it was a herx

where do you buy your MB from garzie? those online websites you shared before?
Posted 3/5/2024 11:46 AM (GMT 0)
i buy it from a source in the UK that another member here had tested for heavy metals and it came back OK

i can email you if your email is active in your profile
Posted 3/5/2024 12:51 PM (GMT 0)
I'm on MB and it helped my brain fog and bladder cystitis. You need to drink lots of water.
Posted 3/6/2024 1:41 PM (GMT 0)
I have not used Methylene Blue, but my doctor did offer it at one point.

I am curious about it. If Methylene Blue reverses symptoms for you, how long do you have to stay on it for the effects to be permanent and be in remission?
Posted 3/6/2024 5:09 PM (GMT 0)
WF, I wish I new. I'm two months in, definitely not cured just helping for now.
Posted 3/6/2024 5:35 PM (GMT 0)
i think its best viewed as a supportive when used in 50 to 200 mg a day

the effects on mood and mitochondria etc are reversible - ie last only as long as you take it

the antimicrobial effects are - like any abx - my be permanent if you do manage to get into remission.
it seems likely that the 50-100mg a day doses will act somewhat synergistically with antibiotics like macrolides and rifampicin - but most lab trials of this action are done in the test tube with much higher concentrations - so its not really clear how much help it is at this much lower dose level

in contrast - it was used at 600-900mg a day for malaria - and Dr H used it at this level as a 2nd or 3rd persister drug against bart and lyme - for 6-7days continuous in his recent high dose pulsed dapsone trails.

unfortunately the side effects and risk also go up with dose
✚ New Topic ✚ Reply