Biofilm Breakers?

I'm wondering what time to take biofilm breakers? this is my current routine:

I take amoxicillin antibiotic 4 days a week (because I'm weaning off). I take it at 1pm, 4pm and 8pm.

I also take a probiotic on these days at 11am so it's 2 hours away from the antibiotic.

I'm adding in biofilm breaker, I have serrapeptase already at home so I'm going to start with that. Can I take it at 11am with the probiotic? or should it be away from it e.g. at 10am?

I also take artemesia 3 days per week, on the days I don't take the antibiotic. Do I need to take biofilm breaker on these days? or only on the days with the antibiotic?

thank you!

in general - enzymes for systemic effects ( which trying to break biofilms throughout the body is ) are usually taken on an empty stomach at least 1hrs before or at least 2hrs after food

they don't need to be taken away from antibiotics