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New study on Artesunate for Babesia - a derivative of artemisinin

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Posted 5/24/2024 1:13 PM (GMT 0)
Short abstract: https://pubmed.ncbi.nlm.nih.gov/38784653/

Full study: https://www.frontiersin.org/articles/10.3389/fvets.2024.1383291/full

Some highlights:

- It's a mouse study where they looked at the drug artesunate to treat babesia (keep in mind that this is not the same as artemisinin/artemisia but it's a derivative of that).

- Artesunate significantly reduced the amount of babesia in the mice's blood and the effect was stronger at higher doses.

- It also helped restore normal function to their liver and spleen. Where it reduced inflammation and damage in the mice's livers. This is huge because artemisia (the herb) is known to cause liver issues.

- And it also affected the activity of proteins involved in cell death and inflammation in the liver, with higher doses leading to decreased levels of proteins that promote cell death (and increased levels of proteins that reduce inflammation).

Take care!
Posted 5/24/2024 1:17 PM (GMT 0)
Sup Rainman
Posted 5/24/2024 1:20 PM (GMT 0)
Hi Blazer! 😃
Posted 5/24/2024 2:28 PM (GMT 0)
I'm always a bit slow catching on to exactly what some studies are saying. So this is just part of artemisinin?
Posted 5/24/2024 3:45 PM (GMT 0)
This is available as an rx?
Posted 5/24/2024 5:05 PM (GMT 0)
there is some research in the last few years showing artemisia and its derivatives are more active for B. Microti - than they are for the other main variants that are thought to affect humans B. Duncani, B.Odecoilei and B. Divergens

i only mention it as the study was done on Microti only and so its findings may not fully generalise to the other main babesia species of interest

it seems microti is in one clade of species and the other 3 are in another - the second group are genetically quite a bit different to Microti - which has a much smaller genome so much so that there was talk of placing it in a sperate genus to the others all together - so it may turn out that the species with the larger genomes have additional genes that allow them to tolerate artemisinins better

artensuate is a semisynthetic derivative of artemisinin
this usually means they have taken the naturally occurring plant compound and added chemical groups to it ( or sometimes taken them away or substituted them ) to produce a chemical with more desirable properties
in the case of artensuate - i think it was to improve water solubility - and hence bio-availability

anyway - hope the additional background is helpful

all the best
Posted 5/24/2024 8:51 PM (GMT 0)
Hey running wild!

I hope you are doing well, my friend.

It's a a semi-synthetic derivative of artemisinin. This means that it is not directly extracted from the plant but produced through a chemical synthesis process starting from the natural artemisinin compound.

To be more exact, they esterified a hydroxyl group of artemisinin and replaced it with a hemisuccinate group. Which makes it more soluble and bioavailable.

It also has faster absorption, a higher peak concentrations and a shorter half-life compared to artemisinin.

Hope all is well! Let me know if you have any other questions, I know you're going to treat Babesia too.

Hey Bailey 🐶 😀 !,

Yes, it's available both orally and as IM injection (and IV too).

Some formulations might have to be acquired through a compounding pharmacy though.
They also sell them at the usual Indian sellers, buy-pharma has the injections for example.

Hope you're doing well!
Posted 5/25/2024 2:03 AM (GMT 0)
thanks for sharing. Artesunate is usually IV in US and hard to get BUT good news it oral artesunate pills are CHEAP from India. Zhang's 'Arte-M' contains artesunate but is pricier then the generic pills from India. Keep in mind Artesunate is a synthetic derivative of Artemisinin.
Posted 5/25/2024 10:27 AM (GMT 0)
Thank you omega33, that's great to know! I might have to order some 🙂
Posted 5/26/2024 2:05 PM (GMT 0)
there is also an special artemisa breed in germany. They called it artemisa a3 its 20x more potent! they breed it specialy for malaria.
i just plant the A3 this year, so i can update you in autum ;)
but anway you can buy the powder and the suggest 3mg of tea per day.
Posted 5/26/2024 5:32 PM (GMT 0)
That's very interesting palermo, can you tell us more about that? Was it difficult to get the seeds?
Posted 5/27/2024 3:54 PM (GMT 0)
so there is a german fb group, and they exchange a lot of plants and stuff. So a group member gave me some plants. but there is this doctor he wrote a lot about it. he specally did it to support africa and malaria...
its the link
https://anamed.org/de/a-3-eine-revolution.html
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