HLA status & methylation

hello, kind healing well members,

i am not a frequent poster, but am just starting to get into the thick of the treatment journey and am looking for some guidance.

after 2.5 years of undiagnosed symptoms (primarily neuro), and many fears that i had MS, i tested positive for lyme bands 41 & 31 on IgG via igenex and had very high titers for rickettsia. i'm allergic to most abx, so i recently consulted with a lyme literate naturopath rather than go through the abx desensitization process at this point.

he did a metals challenge urine test and HLA status blood work. turns out i have what he referred to as the 4353 genotype which indicates heightened sensitivity to metals and impaired methylation, and my urine test showed extremely elevated mercury, lead and gadolinium from all the MRIs w/ contrast i've had in my quest for diagnosis. i do not have the mutation for lyme & mold sensitivity.

i just started the yasko methylation protocol the other day and after 2 days, i was completely body slammed--could barely pull myself out of bed and sit upright. i am now staggering it to every other day rather than every day per my LLND's instructions.

has anyone here undergone this process, and if so, how long did it take before you noticed any difference? i know this is just the first stretch of a long road, and that nothing can be rushed. i just wanted to get an idea about what kind of time frame my family and i may be looking at.

blessings to you all~
binx

Binx,

Have you checked for thick blood?

ISAC panel by Lab corp Esoteric lab?

I had to go on heparin shots to thin my blood before i could do any heavy metal detoxing.

the first one I did I felt better. I did another one a couple weeks fter and felt like crushed glass in my head and entire body.

coffee enemas actually help with this. and supposedly spirolina.

Is this an IV detox?

thank you, achievinggrace, for the bump, and to bucci and yazzer for your replies.

i have not been checked for thick blood, although i did have a post-surgical DVT last december after spinal surgery. i was on coumadin for 6 months and now take ginkgo and a baby aspirin to keep things flowing. i will ask my LLND about the ISAC panel during my next appointment on 12/5.

the detox protocol is all oral at this point--you can look up the yasko protocol to see the details, but it's primarily folate, a neuro-support vitamin, B12 megadose and a couple other things i cannot recall right now. i have everything sorted into a pill box so i don't remember all the details. i am also taking an oral liver support med and homeopathic kidney support tonic to help the process along. i will start an EDTA suppository later on in the process once i am stabliized.

i am actually doing a little better this week, thank heavens. last week was really scary. i sometimes feel like i'm going to drop dead--dramatic i know, but it's the truth.

thanks for the support.

hugs,
binx

Binx - my LLMD (and Dr. Burrascano) generally work under the premise that the Lyme is the main culprit and the other things (metals, mold, viruses, etc.) are exacerbaters of the disease. Lyme uses the mercury to help form biofilms and the other things just take advantage of Lyme's ability as an immunosupressor AND it clogs up your detox pathways as you treat it.  So, the theory from their standpoint is generally, you go after the Lyme first and then, if no improvement, then you begin to start trying to peel away at the other things.

My issues are Lyme and mercury. Mercury causes my worst symptoms (and practically all mine are neuro) I believe but that is because my detox pathways get sluggish and my body can not rid itself of toxins (including Hg) as well. What has worked for me so far is to kill the Lyme - slowly and deliberately so as not to get too detox burdened - and detox the hell out of things through any support means I can  - LOL!  After 4 1/2 months on the abx, I am really seeing very noticeable improvements. I wanted to attack the mercury head on but was advised NOT to do that until we control the Lyme better and get my immune system back up to par.

Plus, I still have to get to the Flagyl part of my abx treatment - something that has been hard for me so far. I think it's because I have had Lyme so long and a lot of it may be in cyst form - the very thing Flagyl annihilates. If my "getting better" trend holds for the next 2 weeks or so, I will work a tiny bit of Flagyl into my regimen.  But, the Yasko methylation stuff seems to have worked very well for me - I have been doing it for 5 weeks now - esp. improved my sleep and that makes a big difference in my health!  These are just my experiences - yours may be different!

Yazzer