Hey Yogi, for those that don't have pain keeping us awake and fit here, this may be new to you.
I had 0-3 hours many many nights and up for 24- 48 hours no sleep when brain buzzing, electric charge feel in brain, ammonia inside, all that was super bad. Broken sleep since Oct 2012 and short
It's only now (the last 4 weeks) since addressing bart co-infection pharma abx went from 0-3 to 5 plus off on broken awake every hour as I still feel my inside head stuff and overstimulation but it's a start.
A miracle really to see a correlation adding a pharma abx drug abx, brain herxing, then finally overstimulation going down somewhat allowing me to go BACK to sleep even if just another hour or 2.
A few I've gotten back to sleep even after 3 wake ups stretching my sleep timeline to 7 broken. From 0-3 broken! Only in the last 4 weeks.
(Taking pharma abx is a stretch for me but I needed them. I say this because I won't take other pharma drugs.)
I believe once I add the Malarone (for babesia) next week after the herxing dieoff my sleep will really come back. I've read a lot on sleep returning for some when they target the coinfections so hope that is the case for me.
Maybe you fit here? I don't know, but wanted to share my experience plus give you another cause for no sleep.
I went and saw a well respected LLMD across the border in the US ( I live in Canada and the community is super shut for us here) to make sure I was on the right track and I could finally talk without stuttering..........
..........."what is the science behind insomnia, broken sleep, frequent awakenings etc when it is NOT from adrenals/cortisol or physical pain causing it?"
He said it was due to cytokine storms affecting hypothalamus so..................this says it better than me so I"ll just excerpt the link.
http://ndnr.com/web-articles/anxietydepressionmental-health/hidden-causes-of-insomnia/
======
Undiagnosed Infections
An infection typically results in an immune response that includes T-cell activation, the release of cytokines, and the production of immunoglobulins. The immune system responds to an infection by mobilizing antigen-presenting cells, engulfing the infectious organisms, and then presenting parts of them to T cells. T-cell activation results in the differentiation of cells that in turn promote cellular (helper T cell, subtype 1 [TH1]) and humoral (TH2) immunity.
Proinflammatory cytokines are released, which can lead to hypothalamic dysfunction, stimulation of norepinephrine release, and alterations in the sleep cycle (illustrated in case 1).
The TH2 stimulation results in the activation of B cells and the production of immunoglobulins. Immunoglobulins against certain infectious pathogens have the potential to cross-react with cellular receptors, including ones expressed in the brain (illustrated in case 2).
=========
This is from the link too, it's about
lyme. And below that in the top link it talks about
the effect from the GUT as well.
Case 1
Lyme disease is caused by 3 species of bacteria belonging to the genus Borrelia (B burgdorferi, B afzelii, and B garinii), which have evolved to hide from a host’s immune system.
Biochemically, the elevation in cytokine levels and the alterations in the hypothalamic-pituitary-adrenal axis can manifest as anxiety, depression, and insomnia.
How bout that?
=========
And Gut, many of us sure have gut problems in this due to the pathogens too right.
First Do No Harm (ie, Rule Out the Gut)
Investigations into immune disturbances are difficult, but this task becomes exponentially harder when a patient also presents with a compromised gastrointestinal tract. The small intestine is the largest internal immune organ, housing 80% of the body’s antigen-presenting cells, whose job is to patrol for pathogens and antigens. Once an antigen-presenting cell (dendritic cell, macrophage, or B cell) binds to an antigen, it undergoes maturation, which results in the release of large quantities of the stimulating neurotransmitter glutamic acid. Elevations in glutamic acid are neuroexcitatory and neurotoxic.
The excitatory effects of glutamic acid are typically offset by the calming and membrane-repolarizing GABA, but this balancing act can become overwhelmed and result in excitability and insomnia (illustrated in case 3)
Post Edited (runner64) : 6/3/2013 11:10:25 AM (GMT-6)