I didn't have any side effects from Rifampicin, but I herxed on it, pretty bad, but not as bad as on Minocyclin and Azythromycin. I herx bad, worse and worst - lol.
My sister had a huge reaction caused by the Rif: a terrible candida outbreak, she was treated for it with Nystatin (THANK you again Summer16), and then started again on Rif, and is doing fine, no horrible herxing... she handles it very well now.