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MTHFR mutation - detoxing

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Posted 5/13/2014 6:57 AM (GMT 0)
i have the a1298c mutation for MTHFR. does anyone else have this? how do i prepare my body for detoxing and herx flares?
Posted 5/13/2014 7:31 AM (GMT 0)
Yes, I have this too. Need to supplement with methylfolate, or 5-methyltetrahydrofolate and Vitamin B12 (preferably methylcobolamin or hydroxycobolamin).

Try to avoid supplements and foods fortified with Folic Acid (the synthetic version of folate, which the mutation in MTHFR makes hard to convert to the active methylfolate form).
Posted 5/13/2014 1:01 PM (GMT 0)
I have that too, only worse than yours. I think that most people with chronic Lyme have it only have not been tested for it. Same with mold and HLA markers. I think that everyone who gets Lyme or any of the coinfections should be tested for both MTHFR and HLA mutations (and mold). If you don't know you have it you will never get better regardless what you do. Good luck and I am glad you were tested and can take care of yourself!
Posted 5/13/2014 1:03 PM (GMT 0)
Sorry just realized I did not answer your questions. Agree with what Razzle said. I resolved the folic acid issue by going on a gluten free diet as most gluten free foods are not fortified (except most rice so you need to read the packaging).
Posted 5/13/2014 1:45 PM (GMT 0)
I am compound heterozygous for both C667T and A1278C. My LLMD prescribed Deplin, but it was too expensive even with my insurance, so I take the 5-MTHR. I was taking B complex, but I looked at the ingredients and saw Folic acid, which is a big no-no for the mutation. So now I take Methyl B-12 (methylcobolamin).

The 5-MTHR at first made me really dizzy, but then I felt huge improvements in terms of my energy after a few days. Did you get your homocysteine and C-Reactive protein tested as well? You should really have a baseline with these readings....I read a lot of scary stuff about the MTHFR mutations and how most people have this, yet don't know. But, the good news is it's easily maintained by supplements. I read that this is probably the single most important test one could get, that could save lives.
Posted 5/13/2014 11:19 PM (GMT 0)
what is the difference between 5-MTHFR and Methyl b12? Is the 5-MTHFR by thorne research? thanks
Posted 5/13/2014 11:20 PM (GMT 0)
and also, is methylfolate difference from methylcobalmin? confused!
Posted 5/13/2014 11:48 PM (GMT 0)
Hi rnbelle ... methylcobalamin is a form of Vitamin B12 ..... Methylfolate ( or 5-MTHFR ) of a form of folate and is considered Vitamin B9 ...

The "methyl" prefix means that these vitamins are already converted to their bioactive form ...

For example, cyanacobalamin is a form of B12 that most simple supplemets contain - but for B12 to be effective in the human body, there are conversions that are required - in other words, an inactive form of B12 needs help being converted into the ACTIVE form of B12 ...

Methylcobalamin is a very active and usable form of B12, but for some people it is difficult to tolerate ...

Everyone is different ... there are many things like zinc, copper, etc that begin this conversion process ... also, there are genetic mutations that people are born with that limit these conversions ...

There is no one-size-fits-all
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