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Anyone with experience taking factive
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Lyme Disease
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LymePickle
Veteran Member
Joined : Mar 2014
Posts : 2132
Posted 5/24/2014 4:29 AM (GMT 0)
I'm seriously contemplating asking my LLD if he will prescribe me factive. I realize the risks of taking fluroquinolones includes possible nerve damage and tendon rupture but I also feel like these risks could be reduced if I take it with curcumin, alpha lipoid acid, and magnesium.
Apparently it can also be pulsed to further reduce the risk, so 5 days on and 5 days off.
I just really want to knock out the remaining infection for good, and from what I'm reading it is absolutely excellent against mycoplasma, Bartonella, and Borrelia. Those are the 3 infections I have, and to have a medication that hits all 3 good AND gets into all my tissues. It seems too good to be true.
I read lots of factive success stories, I know yogi on here finished her Lyme treatment off with factive, and now she's done.
Anybody have any experience with Factive? Or any thoughts even if you haven't taken it?
(gemifloxacin, the 4th generation fluroquinolone)
Tano
Regular Member
Joined : Jan 2014
Posts : 370
Posted 5/24/2014 6:17 AM (GMT 0)
Have you tried everything else ?
Buhner's Bartonella with sida acuta, egcg, houttuynia, knotweed, hawthorne ?
How about
Rifamin w/ Biaxin or Zithromax ?
Ivermectin or Biltricide ?
Ozone or Hydrogen Peroxide ?
When you say "it seems too good to be true" there might be another side
Believe me, there is not a human being on this planet that wants to get back their health more than I do -but I would NOT do Factive or any of those fluroquinolones - my system is too sensitive
Tano
Regular Member
Joined : Jan 2014
Posts : 370
Posted 5/24/2014 6:23 AM (GMT 0)
LymePickle, I just saw another post from you in Yogi's thread .. You said:
For me I was doing so well for the past few weeks and was virtually symptom free ...
Apologies in advance, but if you are / were that close, you are just asking for trouble with Factive ... just keep doing what got you there !!! ... maybe mix it up a little with some different herbs or try adding Low Dose Naltrexone or AHCC for your immune system ...
You're nuts if you try Factive when you are so close ..... and I say that with only the best intentions
Georgia Hunter
Veteran Member
Joined : May 2012
Posts : 2688
Posted 5/24/2014 10:38 AM (GMT 0)
None of the quinolones will have much effect against Borrelia. If I was feeling better like you seem to be, I wouldn't take Factive. When weighing the potential benefit vs. the potential risk, the risk outweighs the benefit for someone that is feeling better. To me, it's more of a last resort medication.
Louise74
Veteran Member
Joined : Mar 2014
Posts : 1077
Posted 5/24/2014 1:01 PM (GMT 0)
I would skip it. You have do so well so fast, don't get discouraged. I would give anything to be at almost 100 percent and I would not take levaquin. Read the horror stories of floxing, which is irreversible.
You could also need some time to heal your nerves. Like my ear is really bad. I can't explain it, felt like someone shot a gun next to it or something. My ear drum would rattle and I got loud echo too. During treatment it turned to nasty tinnitus, which was a constant loud ring. Nothing was taking the ring away. But now it's not constant.
I could have mistaken the ring for a new symptom, but in a weird way I think my body might be trying to heal. It takes years for nerves to heal.
I think inositol heals nerves. Maybe do some high potency garlic.
ToddPaul
Veteran Member
Joined : Nov 2012
Posts : 1017
Posted 5/24/2014 2:42 PM (GMT 0)
Georgia- I never thought the quinolones were good against Lyme until I read Dr. Jaller's blog. Here's a quote from him "Cipro and especially Factive are also good Lyme drugs. Factive is a fabulous Lyme drug".
With that being said I would agree with the responses that it's a big risk but only you can decide if you're willing to take that risk. I personally have done very little abx because I have fairly mild symptoms and won't unless I get much worse.
LymePickle
Veteran Member
Joined : Mar 2014
Posts : 2132
Posted 5/24/2014 5:13 PM (GMT 0)
Hi Georgia. I think quinolones do hit Lyme. I have heard stories of people completely knocking it out even after it disseminated and here they are like 10 years later with no relapses. All they did was take cipro. Also in Dr.Hs book it says it hits lyme as well. It's also the only bactericidal drug against mycoplasma. It also is the only way to treat Bart in like 1-3 months. People who do pulses of it are like wow symptom free for the 5 days of the pulse. - including lyme symptoms
Yes I have read the fluroquinolone horror stories, but I have also been able to tolerate anything in my life time, any drug or food. I believe the Fluoroqunionlone horror stories happened to people who didn't take the magnesium, curcumin, and alpha lipoid acid. I also believe in the body's ability to heal with omega 3 fats and nerve healthy supplements.
I'm frustrated because I literally plateaued at 98%. I was at 99% just 2-3 weeks ago. My symptom is tingles in my brain which is more or less continuos and really concerns me. I just want a drug to clear up what is left. Also I do still have very minor Bartonella symptoms that come and go, some burning like inflammation in the joints. I know lyme does this too but it is a different kind of feeling in the joints.
Tano- good suggestion on the LDN! I'm going to bring that up today too with my Lyme Doctor.
Georgia Hunter
Veteran Member
Joined : May 2012
Posts : 2688
Posted 5/24/2014 5:39 PM (GMT 0)
I was going by what my LLMD told me. He's treated Lyme for 25 years and maybe he hasn't used Factive. I haven't read the success stories like many of you have, I stay in the literature. It serves me well to do that but success stories is what it's about
. Factive is fairly lipophillic and should penetrate most tissues, I just haven't seen it used to kill any spirochetes. IMO, borellia isn't that hard to kill with antibiotics, but it is hard to eradicate them. Amoxil will kill borellia in some circumstances, other times it can't penetrate and L-forms are hopeless. I hope Factive can kill borellia because that gives us another weapon in the arsenal. I'll be reading some references on it tonight.
LymePickle
Veteran Member
Joined : Mar 2014
Posts : 2132
Posted 5/24/2014 7:07 PM (GMT 0)
Yes... See a drug like Factive is excellent at hitting intracellular forms. And yes, it gets distributed very well throughout the body not only because it is lipophilic, but it ALSO bas a fluorine attached to it which literally gives it an extra kick for tissue penetration ability as well.
LymePickle
Veteran Member
Joined : Mar 2014
Posts : 2132
Posted 5/24/2014 10:22 PM (GMT 0)
Well I talked to my Lyme Doctor and he is adding in the low dose naltrexone. He said he's pretty happy with my progress and said I may not need to add in the factive yet but he agreed if I don't improve in 2 weeks he'll add it in. He also agreed that people usually don't have issues with the curcumin, magnesium, and alpha lipoic acid when taking quinolones and these protect against lots of the harmful effects of these drugs.
So we will see, if I don't improve in 2 weeks time we are adding in factive to finish it off. I realize the risks that are reduced by taking supplements but I still prefer to just knock it out and be done with treatment.
Tano
Regular Member
Joined : Jan 2014
Posts : 370
Posted 5/25/2014 4:07 AM (GMT 0)
LP, that is great that you will begin LDN
but, but, but !!!
So many accounts I have read about
tell of people who needed up to 3-6 months to really see the benefits ...
esp if you have a "herx-like" reaction, you gotta stick w/ it !!!
JUST SAY NO TO FACTIVE
;)
Georgia Hunter
Veteran Member
Joined : May 2012
Posts : 2688
Posted 5/25/2014 8:51 AM (GMT 0)
It appears that the new quinolones are effective against Borrelia but the older ones are not. Factive would be the best choice because I've never even seen the other medications before (and I see a lot of meds.)
http://aac.asm.org/content/45/9/2486.short
summer16
Veteran Member
Joined : Jul 2012
Posts : 1417
Posted 5/25/2014 1:11 PM (GMT 0)
Two days after taking a fluoroquinolone (Levaquin)I was sent me into a neurological mess.....over 90 symptoms. My LLMD will not use these drugs as he does understand fluoroquinolone toxicity. Please read more info on these drugs.
Patty
LymePickle
Veteran Member
Joined : Mar 2014
Posts : 2132
Posted 5/25/2014 4:17 PM (GMT 0)
You actually have to do magenesium loading where you load your body up with magnesium, alpha lipoic acid (r-form), and curcumin.
Patty - Did any of you do this? Obviously if I try it, even with the "pre-loading" of nutrients and I get any symptoms I will stop right away. Also I will do the 5 day pulses. Your 90 symptoms could also be related to a herx?
I did do lots of reading and to be honest I'm really on the fence about
it. This really is the best option to hit 3 birds with one stone and would hit them really well too so they all don't come back! But on the other hand you have these quinolone horror stories of some serious damage done some people even needing surgery. But you also have quinolone success stories where the people took the drug and it was tolerated well with no issues at all and it worked effectively well. In these cases the drug was taken with the magnesium, ALA, and curcumin to protect the nerves and tendons.
LymePickle
Veteran Member
Joined : Mar 2014
Posts : 2132
Posted 5/25/2014 4:31 PM (GMT 0)
Georgia - thanks for that article! Looks like factive really is the best of all the options to choose for knocking out Borrelia! The lowest MBC for sure.
Y o g i
Regular Member
Joined : Apr 2013
Posts : 392
Posted 5/25/2014 4:38 PM (GMT 0)
Pickle-- everyone seems to have different reactions to all of these treatments huh? I know the majority say dont take Factive. I might be the minority (and after the hives went away ) I believe taking it for 2 months blasted out the remaining infections.
Other than hives I had NO other side effects. I stopped attending bootcamp due to being concerned about
the reported ligament damage-- and nothing happened.
And my LLmD has had excellent results and seems to prescribe it often.
I would order from northwestpharmacy to save you thousands!!!
Holding the space,
Sarah
Georgia Hunter
Veteran Member
Joined : May 2012
Posts : 2688
Posted 5/25/2014 7:42 PM (GMT 0)
I took Levaquin for a month but I preloaded prior to taking it. I had no side effects but saw no benefits either.
LymePickle
Veteran Member
Joined : Mar 2014
Posts : 2132
Posted 5/25/2014 10:44 PM (GMT 0)
Hi Yogi, I'm glad you chimed in on this. Did you pulse it or use it continuously for the 2 months. Also did you load up with magnesium ? Or did your LLMD prescribe anything to protect from the toxic effects?
Y o g i
Regular Member
Joined : Apr 2013
Posts : 392
Posted 5/27/2014 2:11 AM (GMT 0)
Pickle- my LLmD had me on Fictive continuously for 2 months-- no pulsing this one.
He did not have me load up with Mag.. Or anything else. He just instructed me to be mindful about
my body...And I stayed away from Mag supplements due to hearing it feeds the bacteria. I understand how important Magnesium is for so many bodily functions-- but during treatment stayed away from supplementation.
What are the other side effects of that class of drugs?
For me during this treatment ignorance was bliss.... Not knowing much about
the typical side effects of Abx gave me less things to freak put about
.
Have you found hour HH tea? I'm sorry I haven't looked up where I sourced that.
LymePickle
Veteran Member
Joined : Mar 2014
Posts : 2132
Posted 5/27/2014 3:14 AM (GMT 0)
Yogi, did he have you take it 1 pill a day or 2 pills? Ya it is so hard to know for sure how our bodies will react to certain medications, some people can take these quinolones no problem and then some have some serious long term side effects.
Did you get any nerve damage? You said only got hives. And now you are fully recovered, I like your story.
YES... Magnesium feeds them. I'm going to cut out magnesium. At least for now.
The side effects of the Fluorquinolones are actually unbelievable. It could be nothing at all and be well tolerated or perhaps just minor side effects like you had. BUT, some people could have tendon rupture like Achilles' tendon rupture or nerve damage where they always feel like the nerves are burning. There are cases where it has ruined peoples lives even.
But there is no doubt it is highly effective antibiotic.
Revive
Veteran Member
Joined : Dec 2013
Posts : 1293
Posted 5/27/2014 1:08 PM (GMT 0)
I would definitely read that BLACK box warning before taking it, I personally would not take it. There are so many other things out there to take.
If you decide to be careful and I pray you have no bad effects from it.
LymePickle
Veteran Member
Joined : Mar 2014
Posts : 2132
Posted 5/27/2014 3:02 PM (GMT 0)
Revive - I live in Canada and we don't have black box warnings here for our drugs from the pharmacy. My tinidazole just comes from a compound pharmacy and no black box warnings on that one either. I am risking gene mutations and cancer every day I take it.
I already know about
the risk of tendon rupture. You have to weigh the risks and benefits... Having a chronic disease for the rest of my life or tendon rupture? My infection is 6 months now, and I have treated it well but I plateaued, I might want to just knock the rest of it out. With 2 weeks of this.
summer16
Veteran Member
Joined : Jul 2012
Posts : 1417
Posted 5/27/2014 3:36 PM (GMT 0)
LymePickle,
No, I did not do any magnesium pre-loading. I took 2 doses of Levaquin for bronchitis and within 48 hours I experienced neurological symptoms (extreme anxiety, many panic attacks, no sleep for 8 days, hallucinations, sob, increased mucous production, cog fog, memory loss, etc.) and I immediately stopped this antibiotic. I do believe that after 1 year of experiencing the side effects of Levaquin that my immune system took such a bad hit which brought about
dormant Lyme's disease and its co-inections. I did read an article about
this occurence and I am unable to find it after much research.
By the way, some people do not experience side effects of fluoroquinolones until months later. One may be able to take a round of this med but if perscribed again symptoms can occur. I would NEVER take this med again even if it meant I would die. Why take a chance?????
Patty
Y o g i
Regular Member
Joined : Apr 2013
Posts : 392
Posted 5/27/2014 4:15 PM (GMT 0)
Pickle -- no nerve problems. No side effects (except the allergic reaction to Factive) -- I took the 1st dose and spent an hour or so in the 100 degree sun out in the desert. No wonder I got hives. The Factive cost about
$100 something for 5 pills --urrrrrr.
So my Dr was so convinced It would eradicate the Bart that he asked if I'd try it again. Thought he was nuts.... But decided to do so. This time I ordered from that overseas pharm. the box looked as if it had been sitting on the counter for decades (haaaa!)
I took 1 pill a day- can find out dosage if you want.
Don't get me wrong... I was SOOoo nauseous and toxic by the end of the 2 months-- in fact I think I was planning to take for 2.5 months but stopped 2 weeks early b/c. I felt so toxic.
That's when I did the 10-day cleanse and 10 consec colonics. And after a few months felt great!!! I stopped Factive and all herbs in Dec. 2013 after 9 months of continuous treatment and my life and health are back completely.. Good luck with your decision!! You'll blast it out too I'm sure whichever method you choose.
Yogi hugs-
LymePickle
Veteran Member
Joined : Mar 2014
Posts : 2132
Posted 5/27/2014 4:46 PM (GMT 0)
Yogi, Must be good to clear that infection out for good! Congrats on doing that... Lyme is not an easy disease to get over as all of us that have it know! I have been pretty good but I plateaued at 98-99% in the past 4 weeks and it feels like I just can't get past the last residual symptoms! I too have been consistent and haven't missed a dose of abx. Maybe I need to do some colonics and cleanse my body! Get the toxins out.
By the time you did the Factive, were you still on the omnicef, minocycline, and tinidazole? Or did you just take Factive by itself?
If I take it I am going to combine it with minocycline and plaquenil... But who knows maybe I need to just take it by itself?
If I don't do the factive yet, I may ask my Doctor if he could prescribe me the cephalosporin you are on? But he thinks minocycline and a cephalosporin don't mix because the bacteria need to grow in order for a cell wall drug to work. The minocycline stops their growth. But it sounds like it worked well for you.
As for cost of factive... Well I think it's expensive because it is really a new antibiotic, highly effective, but also has a risk associated with it's use. I don't think it is too expensive here in Canada, but it might be still more expensive than most of the other abx.
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