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MTHFR....again

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Posted 6/8/2014 4:38 PM (GMT 0)
Will some of you please share what you are taking for A1298c and 6677T mutations?  I want to see if I am on the right track.

Patty

Posted 6/8/2014 7:24 PM (GMT 0)
I just watched a video on youtube yesterday that said sublingual methylcomalamine (B12) or Deplin (B9). The video claimed most methylated B9 vitamins are not going to do the job because they are not methylated correctly. If that is true I don't know. I would really like to hear from someone too because now I am concerned. I thought that any methylated B9 was fine to take. Does anyone know?
Posted 6/8/2014 10:30 PM (GMT 0)
Lymebabe, I think we both need some guidance on this.  Hopefully, we'll get some responses.

Patty

Posted 6/9/2014 4:29 AM (GMT 0)
My doctor keeps it simple and has me take Methyl-Guard Plus by Thorne and Basic nutrients 2xday
Posted 6/9/2014 4:35 AM (GMT 0)
MTHFR needs methylated folate and hydroxy-b12 or methyl-b12.

The MTHFR gene mutations prevent efficient conversion of Folic Acid to 5-methyltetrahydrofolate (active folate), but if you just take the active folate without B12, there could be problems with B12 recycling that would potentially cause other issues.

Thus, both B12 and folate are needed with the MTHFR mutations.

Basic Nutrients 2/Day + MethylGuard Plus may or may not provide sufficient active folate...it depends on gender, age, absorption, and dozens of other variables.

Start slowly - when methylation is blocked or significantly slowed down by the MTHFR mutation(s), taking too much active folate initially can trigger significant detoxing and be quite uncomfortable (i.e., it can make you feel terrible!)...

Thorne also makes 5-MTHF in 1mg and 5mg doses. Some may need this in addition to the MethylGuard & Basic Nutrients 2/Day.
Posted 6/9/2014 5:26 AM (GMT 0)
Thanks Razzle I will ask Dr if I should add 5-MTHF.
Posted 6/9/2014 6:58 AM (GMT 0)
I would highly recommend the simple saliva test thru "23andMe" - you don't need a doc, but to understand the results, a doc would be helpful ( to say the least )

There are a myriad of other SNPs that you will need to know about ..

This link is completely intimidating and confusing, but if you feel adventurous, try to read about some of the other genetic issues ... Some things need addressing before the MTHFR ( as MTHFR is just one of a bunch of results you will get )

www.heartfixer.com/AMRI-Nutrigenomics.htm

5-MTHF, B6 and B12 are some of the main things with most issues - unfortunately, some people don't do well on B12 ( yours truly ) so it is helpful to have some additional testing .... and remember, it is important that you use "active" forms for certain supplements ... For example, B6 is only useful in the body when it has been converted to P5P - and there are certain genetic issues that require help in this conversion ...

So while taking B6 might seem necessary, you might actually be doing harm if your body cannot convert it to its active form of P5P .... P5P can be supplemented - in other words, you would take the ALREADY CONVERTED form of B6 which your body could then put to use ...

I would really recommend the 23andMe test

Post Edited (Tano) : 6/9/2014 1:03:05 AM (GMT-6)

Posted 6/9/2014 11:15 AM (GMT 0)

Tano said...
I would highly recommend the simple saliva test thru "23andMe" - you don't need a doc, but to understand the results, a doc would be helpful ( to say the least )

There are a myriad of other SNPs that you will need to know about ..

This link is completely intimidating and confusing, but if you feel adventurous, try to read about some of the other genetic issues ... Some things need addressing before the MTHFR ( as MTHFR is just one of a bunch of results you will get )

www.heartfixer.com/AMRI-Nutrigenomics.htm

5-MTHF, B6 and B12 are some of the main things with most issues - unfortunately, some people don't do well on B12 ( yours truly ) so it is helpful to have some additional testing .... and remember, it is important that you use "active" forms for certain supplements ... For example, B6 is only useful in the body when it has been converted to P5P - and there are certain genetic issues that require help in this conversion ...

So while taking B6 might seem necessary, you might actually be doing harm if your body cannot convert it to its active form of P5P .... P5P can be supplemented - in other words, you would take the ALREADY CONVERTED form of B6 which your body could then put to use ...

I would really recommend the 23andMe test

And P5P can be bad if you have a 699T CBS upregulation.

Good luck finding a doctor that knows anything about the methylation pathway. Every one of the ones I've asked have no clue. I ask everyone of them I talk to.

Tano, sounds like you are an over methylator. There is a small percentage of people that are. I'd have to do some research, but I believe adenosyl-B12 would be the correct form for you and it wouldn't be in high doses.
Posted 6/9/2014 2:16 PM (GMT 0)
Thank you for your answers and insight.  I am still a bit confused but you have given me more answers to help with my research. 

Patty

Posted 6/9/2014 6:18 PM (GMT 0)

Georgia Hunter said...

Tano said...
I would highly recommend the simple saliva test thru "23andMe" - you don't need a doc, but to understand the results, a doc would be helpful ( to say the least )

There are a myriad of other SNPs that you will need to know about ..

This link is completely intimidating and confusing, but if you feel adventurous, try to read about some of the other genetic issues ... Some things need addressing before the MTHFR ( as MTHFR is just one of a bunch of results you will get )

www.heartfixer.com/AMRI-Nutrigenomics.htm

5-MTHF, B6 and B12 are some of the main things with most issues - unfortunately, some people don't do well on B12 ( yours truly ) so it is helpful to have some additional testing .... and remember, it is important that you use "active" forms for certain supplements ... For example, B6 is only useful in the body when it has been converted to P5P - and there are certain genetic issues that require help in this conversion ...

So while taking B6 might seem necessary, you might actually be doing harm if your body cannot convert it to its active form of P5P .... P5P can be supplemented - in other words, you would take the ALREADY CONVERTED form of B6 which your body could then put to use ...

I would really recommend the 23andMe test




Tano, sounds like you are an over methylator. There is a small percentage of people that are. I'd have to do some research, but I believe adenosyl-B12 would be the correct form for you and it wouldn't be in high doses.

Thanks GH, I have suspected that - but I have yet to try adenosyl-B12 ... Thank you again for the recommendation ...
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