Yes the research was done with flagyl, but with much higher dosing and for long periods of time. Also I think my LLMD said it was done on mice and rats, and then they tested it in hamsters and it didn't affect them?
Tinidazole is generally tolerated better and that is reported by all LLDs and patients as well who have experience taking both.
We can say Tinidazole is similar to flagyl, you see there is a powerful reactive NO2 group on the molecule, you can see on wikipedia if you look at the molecule.
BUT it is not quite as bad as we think. The medication DOES have a tendency to accumulate in anaerobic bacteria. Hence that is why flagyl is the best drug to use to treat anaerobic bacteria infections in the human body. That is it accumulates in places where there is less oxygen. This also happens to be Lyme cysts! Inside the lyme cysts where it accumulates it releases the nitro group and this breaks down the RNA and DNA and some of the enzymes. The sulfur group must do something too... I'm not sure what though.
However... The risk is NOT just cancer. The drug also damages our mitochondria. Keep i mind our mitochondria also have their own DNA and RNA and they make their own proteins and enzymes.
My LLMD and LLND really conflict me on this... I asked them both 'well what about the cancer risk'... Their response was almost identical, basically they said you are not taking it in high enough doses and for long enough periods of time to cause cancer. But then when I reported I was feeling toxic the next appointment. (actually the next appointment I had with both of them), they both said okay stop the tinidazole. I got some symptoms back and messaged my LLMD about that and stopping the tinidazole, he said "(insert my real name here), I am not going to be prescribing you anymore tinidazole)". He also said it is causing my feeling of being toxic. He thought because I sent him a panicked message that I wanted to get back on it. Also my LLND said it needs to be stopped and then he stressed the amount of harm it can cause to mitochondria... See so they tell me one thing then they tell me another thing the next consult. My LLND was trying to shift my gears to get me to focus on building my immune system stronger.
Anyways... I think everyone agrees on this tinidazole is the best known cyst buster period. But yes it carries risks. But also realize the medication actually accumulates in places where there is no oxygen and releases the nitro group there such as lyme cysts. Also a good biofilm treatment. Biofilm will not block tinidazole at all but blocks other antibiotics. The tinidazole goes right through biofilms and kills whatever is inside it. Also humans have exceptional DNA repair mechanisms. We can repair our own DNA but it shortens our telomeres when it is repaired. So a little shorter telomere each time it fixes. But you can take TA-65 which lengthens your telomeres after treatment.
Also... I want to say something I have noticed about tinidazole. And I am no Doctor. But, I read the research articles and tinidazole... believe it or not is also effective at low doses! It is typically prescribed by LLMDs at doses of 500 mg twice a day. But then I read a German Lyme Doctors guidelines and she does 250 mg or 500 mg just in the morning! So even a 250 mg pill is enough... And another person cured his Lyme twice taking tinidazole 250 mg every second day! So you don't necessarily even need to use the 1 gram dose and could dose it lower.
If you look at the research you will see tinidazole dosed at 62.5ug/ml, 250ug/ml, and 500 ug/ml... They were all pretty much equally effective in killing Lyme germs! That is what I noticed, so then I thought well what is the point of taking a higher dose then if the lower dose still kills it almost just as effectively. Also another great thing about this drug is yes it gets everywhere throughout the body. Another necessary characteristic of a drug that will treat Lyme well. Some drugs are just too big of a molecule.
The drug does work for Lyme. Even our Dr. K ( Doctor which likes to treat as holistically as possible with minimal amount of abx in Seattle) mentions using tinidazole that I read today.
Post Edited (LymePickle) : 8/14/2014 7:25:01 PM (GMT-6)