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switched to doxy - herx questions

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Posted 9/3/2014 3:50 AM (GMT 0)
Okay, I know I should be "seasoned" enough to know this... However, this is the first time I've completely switched abx.

I was in Zithro from 4/24 (until 3 days ago) 8/30, was on Ceftin for 6 weeks, and stopped both ceftin and zithro (8/30), started doxy on 8/31, and though I was feeling pretty yucky (hence the switch), now almost everything is heightened... My emotions, my pain, my back issues.... But I'm almost positive this shouldn't be a "life cycle", in past months this is my best time....

Any thoughts? Is it because of the switch? If so, why does a switch make you herx if its not during the life cycle...? Shouldn't most of the "bugs" either be dead or "hiding"? Or is doxy just getting to new places, and/or a more effective drug?

Thanks for any words of support/advice/knowledge. In a rough place at the moment.

Post Edited (Delmar) : 9/2/2014 10:10:19 PM (GMT-6)

Posted 9/3/2014 4:04 AM (GMT 0)
I do understand a herx reaction is due to die-off/neurotoxins, but what I don't understand.... Why would there still be so much left to kill after 4 months + abx?? Am I correct with my last question about doxy getting into new places that Zithro/ceftin weren't working on before? Or possibly a confection?

Post Edited (Delmar) : 9/2/2014 10:11:24 PM (GMT-6)

Posted 9/3/2014 6:04 AM (GMT 0)
Delmar - I just switched to Ammox - day 5 today....and I'm wondering if I'm herxing - my nerves are shot - vibrating/buzzing all day...when a couple weeks ago, they were getting better. I'm also nervous today - mind wise.
Hard for me to tell what's going on.
I know what you mean.

I wonder how come when I herxed for 12 days on the doxy that when the herx finished I didn't feel a whole lot better? All that critter killing...I would think I'd had more significant changes for the better after...

I'm wondering like you - maybe bringing out a co? I'm thinking maybe the bart has come to the forefront???
Hopefully in a few days...we'll feel a bit better? Let me know :-)
Posted 9/3/2014 2:47 PM (GMT 0)
Thanks Girlie! Yes, hopefully! You too!
I feel better this morning but that doesn't mean things can go downhill in a hurry. Mornings are always my best time.
Posted 9/3/2014 4:30 PM (GMT 0)
Delmar - me too...mornings are always better. By late-afternoon or evening - look out - I'm usually pretty bad.
For me it is worse if I'm sitting down - as when I stand up everything hurts. don't know why that is.

I'm feeling ok so far today, but it's only 9:30 here...lol.

How are you?
Posted 9/3/2014 4:47 PM (GMT 0)
I think the doxy does sort of get to new territory.  It gets into the brain and intracellular locations better.  Also I think it gets into the nerves better as well. 

The azithromycin doesn't get into the brain.  So doesn't pass through the blood brain barrier.  The ceftin does pass through the blood brain barrier but doesn't get infection that is inside of cells. 

That is why the intracellular antibiotics are needed most in lyme disease.

I switched to biaxin and i got bad muscle burning for 2 weeks!  And now it's clear!  So it does work eventually. 

But I am now on Clarithromycin + minocycline + septra DS... And I feel much better now.  And stabilized.  I still get the odd symptom here and there but I think I got all the territory covered.  I just wish this bartonella was finished!

Posted 9/3/2014 8:29 PM (GMT 0)
Thank you LymePickle! I was hoping you would comment and say something along those lines. That's what I was thinking but its just so discouraging after 4 months on abx to feel so bad, but I guess that's how this thing goes, and different antibiotics are going to go after different things in different places. I hope doxy is a better abx for me.

Girlie - much better day today so far. I'm in KS visiting family it's 2:30 here and I've had very few symptoms today... Some back pain - that's about it (knocking on wood). :) How about you?
Posted 9/3/2014 9:57 PM (GMT 0)
My day is better today, too - so far. It's almost 3:00 p.m. and I'm heading out to my son's for a visit. I'm having upper back pain...but not real bad..and my left shoulder blade is sore...but not too bad either. It's still earlyish...lol

I didn't make sense earlier...about the sitting down. While I'm sitting down i feel okay, but when I stand up after sitting for a long time...i hurt ...don't know why...sometimes I don't even want to sit...because when I stand up I'm so stiff and sore...
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