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Lyme in the brain?

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Posted 9/9/2014 12:07 AM (GMT 0)
Are there any other effective ways of killing lyme in the brain/central system other than iv antibiotics?


Thanks
Posted 9/9/2014 12:42 AM (GMT 0)
Oral antibiotics also work. Many successful practitioners have found that the "low and slow" method is the best approach with a long-held, disseminated infection.
Posted 9/9/2014 12:56 AM (GMT 0)
achievinggrace—

I have read that elsewhere, too. Do you know why that is?

-p
Posted 9/9/2014 1:19 AM (GMT 0)
Achieving Grace - how low and slow do you mean?

I feel like my antibiotic dose is too much. I felt that way on the doxy, and I feel like that now on the ammoxicillin. But, I'm sticking to it...for now.
Posted 9/9/2014 1:38 AM (GMT 0)
Yes there are ways of killing Lyme in the brain.

The top candidates are minocycline and tinidazole. If you take both together it clears all forms of borrelia and takes out brain bio films.

The following is a list of the top abx for brain treatment of borrelia...

Azoles:(kills cyst forms, tind takes out biofilm)
Tinidazole-
Metronidazole-

Cephalosporins cross the blood brain barrier but don't treat intracellularly Lyme (combine with probenecid to increase blood levels):
Ceftin
Supax
Omnicef.

Amoxicillin also crosses the blood brain barrier but doesn't treat intracellularly.

Intracellular drugs:
Minocycline - 40% of dose crosses the blood brain barrier.
Doxycycline - 14% of dose crosses blood brain barrier
Clarithromycin - 5 % of dose crosses blood brain barrier. (But keep in mind this is dosed high like 1 gram a day)
Gemifloxacin- 20% crosses blood brain barrier. (Only fluroquiniolone that is highly effective against borrelia)

If you really want to treat that neuro Lyme , you can do it effectively with oral antibiotics using the above.

A good effective combo would be clarithromycin + minocycline + tinidazole. Or ceftin + minocycline + tinidazole.
Posted 9/9/2014 1:59 AM (GMT 0)
So LP - what if you use an antibiotic for several weeks that kills some lyme in the brain, but then you switch over to one that doesn't get into the brain...then do the lyme critters in the brain really flourish because you've backed off on the antibiotic that gets into the brain?
Posted 9/9/2014 2:24 AM (GMT 0)
Girlie- yes and no. What happens over the course of treatment is that less and less of the Lyme spirochetes choose to reproduce. I think they learn that reproducing will kill them eventually and the ones that are left would rather just live. So they learn that reproducing kills them. After each cycle there are less and less left over, and the ones that are left don't reproduce. So at this point if you switched over to antibiotics that didn't get as good brain penetration, it wouldn't matter since the spirochetes left don't really cause any disease and are kind of the survival ones, they live just to survive but not thrive. For example Zithromax or azithromycin doesn't cross the blood brain barrier at all. Tetracycline I think hardly crosses the brain either. Even rocephin has a hard time crossing the blood brain barrier unless it is inflamed by bacteria and leaky or in an IV dose.

Some people treat only on the days when they may reproduce and start a new cycle as this is when antibiotics really kill them easily.
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