If you stay away from the flavored kefir, it's got a lot less sugar in it or you can make your own as I did.
You need to keep the probiotics 2 hours away from the abx - and it would be best to take them 2 hours
after the abx. This way you are replenishing the flora in the intestine for longer than just 2 hours.
Lyme driven, you may not see any immediate benefit, what it does is keeps you from developing Candida. Candida can really mess up trying to heal from these infections if you have to stop the abx and use only anti-fungals due to a serious Candida infection.