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What do I do about my mthfr mutations??

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Posted 2/23/2015 7:05 PM (GMT 0)
I am heterozygous mthfr 1298 and 03 p39p. Google searching is not working out for me.

Other than that I have COMT homozygous and a bunch of other things. I posted about this once before but I can't find it.

My brain is just..... broken :( thanks for your help.

Is this why I can't detox?
Posted 2/23/2015 7:28 PM (GMT 0)
You probably can't detox because metals have your pathways blocked. Decrease the amount of acidic foods you eat and see if that helps. The mutations you have aren't terrible and you should be able to overcome them if you have sufficient nutrients to drive the pathway. If you don't have enough zinc, copper, manganese, or molybdenum, your pathway won't function even if you have no mutations. Leafy greens, nuts, and seeds are high in these nutrients. And the are either alkaline or only slightly acidic.
Posted 2/23/2015 9:17 PM (GMT 0)
Is that the MTHFR P39P?

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Here's info about the 1298

MTHFR A1298C
MTHFR A1298C is involved in converting 5-methylfolate (5MTHF) to tetrahydrofolate (THF). Unlike MTHFR C677T, the A1298C mutation does not lead to elevated homocysteine levels. This reaction helps generate BH4. BH4 is important for the detoxification of ammonia. The gene is compromised about 70% in MTHFR A1298C (+/+) individuals, and about 30% in people with a heterozygous (+/-) mutation.
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So you're hetero so it means it's 30% compromised. You should try a methyl folate supplement and see how you feel. Not folic acid.

I have a different mutation but I think that's right? Unless you can buy a THF supplement?

Post Edited (sarahm620) : 2/23/2015 2:21:33 PM (GMT-7)

Posted 2/23/2015 9:24 PM (GMT 0)
Here's a thought for those that need/want a doctor to talk about on this: a list of doctors that are supposed to understand methylation issues!!!

mthfr.net/mthfr-resources/
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