Did those with MTHFR gene mutation herx when you first supplemented?

I found out I have the gene mutation and am about to take methyfolate for the first time (I've already been on methylated B-12, before I knew). My doctor said a herx is possible. I just want to have a sense of what I'm in for!! Thanks..

Yeah, that's exactly what I'm asking... My doctor mentioned that because my body has lacked what it needs to properly detox for so long, that finally giving it what it needs could create a major healing/herx reaction.

He suggested taking a dose and then waiting 4 days... Just to take it slow and not cause too much detox at once.. I'm just nervous because it's been such a brutal summer and I'm concerned that my body can't take much more stress right now.

Also make sure that your diet has ample quantities of trace minerals that are substrates for the methylation pathway. Foods high in copper, zinc, and magnesium are important. Selenium is a catalyst for 3 reactions so it is important. Boron, molybdenum, and manganese also have important functions. If you are deficient in any of these elements, your pathway will not function optimally and will suffer. The Terry Wahls diet is the best I have seen at addressing these nutritional deficiencies.

If you have had chronic inflammation for an extended period of time, the odds are high that you are deficient in some of these elements.

To answer your question, when the pathway gets running, metals start moving and that can cause herxing. It wasn't until my pathway became much more functional that I didn't herx when trying to treat pathogens. I can take supplements now that I couldn't take before because my pathway is functioning better.

Hi! I had to go very slow with the Folate. When I took it a few days in a row, I started having such overwhelming fatigue and brain fog. Could barely function. I could only take it every 3-4 days at first. Once I felt fine on that, I started taking it every two days, then every other. Now I take it every day. It took quite a few months before I could take it every day. You might have an easier time since you were taking b12 before starting Folate. I started both at the same time.

marigold33 said...
Thanks so much for the thoughts everyone! I took my first dosage of methylfolate this morning... 1,000 mcg. So far I haven't felt anything worse than how I've generally been feeling.. Certainly not well, but nothing extreme yet that I could pinpoint as specific reaction to it. How long did it take you to get the herx from taking the methylfolate?

I take a bunch of trace minerals daily and will amp that up a bit... Good idea.

I'm thinking I'll wait a few days before taking the methylfolate again, just to be safe.

Minerals need to come from your diet. Vitamins are racemic mixtures and that contains D and L isomers. In essence, only 50% will be chemically available for receptor sites. Vitamins are better than nothing, but fail miserably when compared to equal mineral content from food. That is why Terry Wahls ate her minerals and didn't supplement with them.

It took 22 years but I finally used my 4 years of college chemistry.