Posted 11/20/2015 12:02 AM (GMT 0)
Rifampin does lower the ability of malarone to be absorbed, though I'm not sure by how much. Some people avoid the combo because of this but I've also seen people who knew this and took the combo anyways.
The addition of rifampin to zith/malarone would not do anything more to babesia than just zith/malarone alone because rifampin is not active against babesia.