I've wondered myself about
the difference between Buhner's opinion that Bartonella doesn't cause herxes and all the reports from people on forums about
Bartonella herxes.
I did a quick search and I suspect this is probably one of the papers that informed Buhner's opinion that Bartonella has low endotoxicity:
"Some unusual structural features of the B. henselae lipopolysaccharide, including the presence of a long-chain fatty acid, which are shared by the lipopolysaccharides of other bacteria causing chronic intracellular infections (e.g. Legionella and Chlamydia), may provide the molecular basis for low endotoxic potency."
Structure and biological activity of the short-chain lipopolysaccharide from Bartonella henselae ATCC 49882T.
www.ncbi.nlm.nih.gov/pubmed/14766898So it seems that the Bartonella bacterium itself isn't super toxic. So what to make of all the reports of herxing?
One possibility is that the herb taken is killing some other bacteria that is more toxic.
Another possibility is that since Bartonella is an intracellular pathogen, the herxes are from the debris of our own cells that are killed when we go after Bartonella.
The paper above states that Chlamydia also has low endotoxicity and this one corroborates that:
"The chlamydial LPS were at least 10 times less active than typical endotoxins"
www.ncbi.nlm.nih.gov/pubmed/12542694However the cpnhelp.org message board is filled with people herxing and using binders for the die off from Chlamydia Pneumoniae. They attribute this to toxic heme synthesis byproducts (porphyrins) produced inside cells that Chlamydia has infected and hijacked. Killing the cell releases these toxic metabolites.
So perhaps Bartonella could be doing something similar inside our cells that it infects, and when released these toxins create the herx we feel.