Because band 41 is a major player in Lyme detection - it's just that it only indicates the tail of the bacteria and can cross react with other spirochete bacteria like Pinta, Yaws, Syphilis and Bejel.
Interestingly enough, I just came across my very first WB that was taken 7/2007 and I only had band 23 show as positive - I thought it had been band 41! So, I'm one that never had band 41 show up until after a full year's abx treatment.
Yes that first article says that "26 healthy volunteers" were positive for bands 45 & 58 - but because of the likelihood of them still having the infections and just not having the full positive on the Western Blot (remember we already know that the WB misses about
50% of those that actually have the infection) - are they really not infected, or are they just not producing enough antibodies to the "correct" bands?
Some interesting tid bits from this study though, but we have to remember, these results are due to the specific strain(s) that are in Poland:
"Evaluation of banding pattern in respect to clinical form of the disease revealed the highest prevalence of IgM and IgG anti-41 kDa antibodies in patients with erythema migrans and Lyme arthritis..."
"anti-58 kDa in neuroborreliosis patients, who had no anti-21 kDa antibodies"
"Relatively high frequency of IgG antibodies against 21, 30 and 93 kDa antigens was typical for neuroborreliosis."
"Bands count was significantly higher in different clinical forms of the disease than in controls, and it was the highest in neuroborreliosis."
But I listed that article because it shows that Band 58 is from Lyme most likely, not Bart as Lyme Pickle had posted.
What I find really interesting is that in 2001 (when the article that Beeperoni posted was accepted) they were already thinking that the bacteria can actually change how it's expressed (seen):
"expression of p66 in the outer membrane of B. burgdorferi may change somewhat with either site or duration of infection. For example, p66 has been proposed to be a porin, and the different nutritional requirements of spirochetes in different environments (e.g., central nervous system versus joint) might affect the structure or expression level of the protein. The observation that reactivity to p66 is highest in the late neuroborreliosis patients supports the idea that p66 may be either expressed or processed differently in the nervous system..."
Previously, it was considered a heat shock protein. "Heat shock proteins (HSP) are a group of proteins the expression of which is increased when the cells are exposed to elevated temperatures."
www.sciencedaily.com/terms/heat_shock_protein.htm