Connective Tissue Disease

I had offered to help someone with this a while back but couldn't get the answers I needed to point him in the right direction. I'll just throw a blanket over the condition and if anyone has it, they can make their own decisions.

Connective tissue defects are apparent in homocystinuria, in patients with the oxidation of lysine, and in patients with an oxidation of tropoelastin. This means they have too much oxidation going on and need to reduce their acid load or eat more alkaline foods to reduce oxidaton. Most of the time, there is a deficiency of lysyl oxidase although connective tissue disease can be caused by toxicity from chlorine, bromine, or excessive nitrogen groups. You need to eat less of these. It just so happens that Levaquin is classified as a fluroquinolone and has a fluorine molecule in its chemical structure. Is that a coincidence that it causes connective tissue disease in some?

If I were treating this condition, I'd eat things like apple peal (hard to find organic apples) and rice bran. I'd eat turmeric and evaluate my lysine to arginine ratio. Viral infections tend to skew this ratio. I'd supplement with things like resveratrol, magnesium, lithium orotate, and maybe Vit. B6. These all help in connective tissue formation.

I'd evaluate the lysyl oxidase pathway and make sure I had vital substrates like Fe, Cu, and Mn. Much of the time, it is a copper deficiency that causes the problems. Copper deficiency won't often be picked up on by physicians because the main storage of copper is in the liver and copper is primarily an intracellular element. When intracellular copper levels are low, the liver releases more copper and your plasma concentration of copper will be high. Copper is always bound in our body to transport proteins and when it's not, it forms a harmful hydroxyl free radical that can cause cellular damage. If your GI flora is not conducive to allow more of these transport proteins, you may have problems with copper supplementation. These are all things that should be looked at with connective tissue disorder since chronic infection can reduce copper, lithium, manganese, magnesium, and other essential elements.

It is believed that arginine is utilized during the replication of viruses and protozoans (I don't believe that but it's just semantics) and in chronic cases of diseases from them, your arginine level can get low. If you analyze the foods that you really like to eat and examine what they are made of, you can see how much arginine is in them.

Arginine is a protein that we eat and it is converted to ornithine during the urea cycle (the cycle that helps us get rid of nitrogen). Ornithine is then converted into putresine which is a polyamine. It is my belief that the polyamines are the major problem for chronic Lyme patients. They are essential and very important for many cellular functions. When their numbers start decreasing inside our cells, we start aging and having problems.

When people start to have a bad body odor or smell funny, this is the cycle that is not functioning properly.

Even though arginine is converted to ornithine, this (like many pathways) can go back words and under certain conditions, ornithine can be converted back to arginine. There is a proper ratio between the two and the pathway needs to go forward, not backward. Problems with arginase or the enzymes between the two can cause a backward direction provided the pH of the cytoplasm is conducive for this. Experimenting with what you eat can sometimes help determine what is going on in this pathway.

Here's an example of the pathway, just look at the pics if the terminology is more than you want. Note where collagen synthesis is located. All of these pathways are intertwined and lysyl oxidase deficiency can be just part of the problem if the pathway isn't functioning properly.

ccforum.biomedcentral.com/articles/10.1186/cc11205

Protozoans can sometimes mimic enzymes in this pathway to change the concentrations of vital components.

I had high copper when i was on ABX. I dont know if i did before ABX.

6 months after ABX , my copper is fine per inner cell testing. (Spectro Cell test).

I take L-lysene to lower my c4a immune inflammation marker. My C3a is fine. With lyme both should be high, so Dr thinks its still my body detoxing from past ABX or the leftovers of candida. Did all kinds of virus testing- (the regular ones) cant find any.

Since Last month my muscles are healing to some extent- a change is happening for the good, its very slow, but happening. Same diet too.

I stopped ABX 13 months ago. And had bad candida - with thrush at the 12th month.

Treated candida again mid summer 2015 - this time diflucan, and I herxed on it.

The slow popsitive changes occuring are not due to me killing any bugs inside- I've not taking anything that eradicates anything since last summer.

Rx , herbal, ...nothing........but liver , immune support, and mitochondria support.

I continue to release trigger points daily. Im fixing my frozen shoulder, tight hip and foot. And most other muscles.

I was really tired late fall- my body loves to sleep. I forgot what sleeping was for 20 years. This extra sleeping takes a lot of extra time (no Rx either) I had when I could not sleep, but it must be helping. Hope this continues. I purposly nap 1 hr after work (its winter so why not if I can). Mornings are groggy though since I do take benedrill at night. But that did not make me groggy before. I go in this deep sleep now, my body has not done that since the late teens (product of the 1960's here).

So this is weird in a way.

My wrists tendons are still tired from all this typing. I will never have a desk job that requires a lot of typing, or mouse work- I cant type much- tons of scaring on all tendons. At least they slide now. Wish I was more outgoing- I'd be in face to face sales then.

On with the waiting game.

Astroman, what is your Superoxide Di****ase status? Any mutations to those genes?

I tried SOD, superoxide di****ase for awhile, I did not notice anything. This was per a gene Dr. I dont know what the specific genes deal with this one, but it didnt grab my attention either. I was going to ask the doc about this again.