heterozygous for a1298c and c677t

Since I am on a roll with asking questions is there anyone that can tell me what I should be taking for these gene mutations?  Right now I am taking methyl b12 sl 1000ug daily and P-5-P (b6) daily.  My LLMD said he is not too fond of folate??????  Is there testing that should be done?  The doctor says my pathways are only 30% functioning???  When I question him about this problem he states I should see a doc that specializes in this problem.  I am really so confused.

Patty

Google subject-there are a couple really go sites.
my guess is most chronic people have the same issues

My understanding is this is one of the best sites for MTHFR learning and issues: mthfr.net/ They even explain how to find a good doctor there: mthfr.net/mthfr-resources/

I am Homozygeous for the MTHFR gene (c667t). I am also homo and hetro for a bunch of other stuff. In order to work out what was what I had to do a whole load of reading, and I understand totally your confusion at this point!!

I can tell you that being hetro usually means that your pathways are functioning at up to 70% (for homo it is more like between 20-30%). www.heartfixer.com/AMRI-Nutrigenomics.htm is an excellent place to find put the information you are looking for, but it isn't an easy read.

Basically, for a MTHFR mutation you should be investigating the use is Methyl B12 and Methylfolate (NOT Folic acid!) That said, because you are hetro rather then homo, you may find that a very small amount of supplementation is necessary, some don't need it at all - that's due to the interplay of your different genes and possible mutations.

You should also be aware that over use of these supplements can be as problematic as not taking them at all, particularly methylfolate, who's side effects are very similar to those you can experience from Lyme (Read up here -mthfr.net/methylfolate-side-effects/2012/03/01/)

So, I take 1/5th of a 3000mg Adensyl B12 supplement (I take this rather than methyl B12 due to other mutations) and 1/5th of a 1000mg methylfolate suplement, daily.

Did your doc test for other gene mutations? I ask because these may have a bearing on what you may need to supplement with and in what amounts. I had mine done through 23 and me, but I had to figure out what to do about them without the help of a doctor

Here is most likely what happened. Your pathogens caused you to greatly increase your body's production of nitric oxide. This can cause arginine to be converted to free radicals which can cause cellular damage. Your body recognized the situation and epigenetic shifts occurred to help protect itself from the damage. The good news is that those two mutations can easily be supplemented for. Your eating will need to be consistent. I would check my homocysteine levels because that is very important with these mutations. You don't have a CBS mutation yet and you don't want one.

Eating meat or specifically items containing methionine needs to be consistent and most likely lower. Your homocysteine levels will determine how much meat you should eat. A lot of meat pushes the pathway too much and will make you more prone to have a CBS mutation. Not enough meat and the pathway won't cycle enough. I'm hetero on both of the genes you mentioned but I ate too much protein and have the homozygous CBS mutation and all of the sulfite problems that come with it. I try to eat meat twice a week. I end up eating a couple times more because of my lifestyle but you will have to find a happy medium on methionine intake. Green leafy vegetables would be great to eat for your mutations. Check on the foods you eat and how much arginine they have in them. You may have too much or you may not have enough.

Supplementing with Riboflavin and methyl folate would be good and your dose of methyl folate can be tricky. hHgh dose Vitamin C may also be helpful.