glutathione, and vit c, to combat brain fog and shakiness...? Really?

This site has a lot of information about glutathione (and much of it is about liposomal gluathione since that's the only effective method of oral administration):

www.liposomalglutathione.com/

I've just embarked on yet another N=1 experiment....daily use of soy-free liposomal glutathione for the upcoming month.

I used it once before to help with herxes. Now I'd like to see if it helps with what seem like my final symptoms....not sure if heavy metals are involved (I'm taking other stuff for heavy metals as well but figured I'd see if extra glutathione helps me get over my current hump).

cd: which liposomal glutithione are you using? I found IV for Life soy free on Amazon.

I have been on IV glutathione for over a year. I can't do the oral glutathinone because my gut can't take the sulfur. IV I am good thought with granted it has no alcohol preservative in it cause I am crazy alcohol sensitive. All that nonsense being said here is a quick primer:

www.huffingtonpost.com/dr-mark-hyman/glutathione-the-mother-of_b_530494.html

I swear by it. I am not sure why more people don't use it. A bunch of East coast LLMDs got me started on it. It has basically no side effects unless you have sulfur issues. Many people confuse herxing when first starting it with not working. This is not the case. Generally because it does a such a great job of detoxing and reducing inflammation it primes your body. If you drip it too fast it can make you sick too. It greatly reduced my herxes in general and does a good job at keeping inflammation at bay.

I get the shakes still but no where near as much. Glutathione addresses glutamate storms as well.
www.dana.org/Cerebrum/2007/Protecting_the_Brain_from_a_Glutamate_Storm/

Cd-I somewhat understand where she's getting that from. I have a new cookbook called the anti inflammation cookbook written by Amanda Haas. The recipes follow for the most part the Lyme diet.

She writes in the intro pages-Oxidative stress results from an inability of antioxidants (for example, superoxide di****ase, glutathione, vit c, and vit d) to sufficiently eliminate waste products (such as free radicals and reactive metabolites) that are generated during normal cellular energy production process. Under chronic stress conditions, our bodies have both increased demand to generate energy and decreased capacity to repair the body which results in chronic inflammatory state.

I took this from the web page of one I purchase-You may not be familiar with glutathione‚ but it has several important purposes. It might support liver health and cellular functioning. Furthermore‚ its antioxidant properties may work to protect you from potentially harmful free radicals. When you're under high levels of oxidative stress or exposure to toxins‚ the amount of glutathione present in your body to recycle other antioxidants (such as vitamin E) declines dramatically. As a result‚ your immune system may be weakened and less able to protect you from getting sick.

Glutathione‚ a molecule consisting of the amino acid building blocks glutamine‚ glycine‚ and cysteiene‚ is naturally produced in the human body. Unfortunately‚ certain health conditions may interfere with its production.

The liver contains the highest concentrations of glutathione. This substance may protect liver tissues‚ while supporting phase II detoxification through promoting the removal of toxins through waste products like stool and bile. and the effective metabolism of dietary fats. Finally‚ higher levels of glutathione may maximize your athletic performance by encouraging muscle growth and strength‚ shortening recovery time‚ and boosting physical endurance.

I love when the board randomly decides that a word needs to be censored. It happened there and it happened the other day when I wrote salt water

You're not being dense. The way I think the other poster meant her comments was that if we are subsidizing glutathione then when are bodies are less stressed as we get far in our healing journey are we not inhibiting our bodies ability to generate it during the normal cellular energy production process? It's a valid question and I don't have the answer.

I think we all hope our bodies will return to whatever normal is. Will we be using supplements forever to ensure as best as we can that we don't relapse? That we keep our immune systems running at the best levels possible? I'm willing to do about anything to make sure I'm never an active member of this club again.

Hey astroman,

Sorry to go off on a tangent here.

Has anything that's been shared (even for my benefit) been useful for you? I hope, I hope ;)

Thanks for that fact about Tylenol and glutathione, Jackie Moon!

I've been taking NAC for a very long time now and one reason is the fact that it's a precursor to natural glutathione (as is ALA and a few other things).

I knew that large doses of NAC are given for Tylenol overdose.

I don't take Tylenol because I'm conscious of my liver health.

Glutathione is one of the most important end products of the methylation pathway. It's anti-oxidant capability comes from it's thiol composition containing sulfur molecules. Sulfur is like an electrophillic sponge and binds free radicals and helps the immune system function appropriately. Glutathione is recycled in most people, we Lyme patients aren't so lucky. Over time, constant inflammation takes its toll and our glutathione levels are reduced. Our methylation pathway function and glutathione production decrease because of epigenetic shifts, decreased catalysts and substrates for the methylation pathway, direct metal blockade, and less glutathione recycling because of free radical interaction.

There are other potential causes of glutathione deficiency. Glycine deficiency from a decrease in CGAT or SHMT2 gene function can lead to lower glutathione levels. Many bacteria and pathogens utilize glycine during their life cycle because it is the simplest of the amino acids. This can lead to glycine deficiency. People with CBS mutations don't recycle homocysteine which will decrease glutathione production. These people don't tolerate sulfur or thiol levels very well either so supplementing with glutathione precursors like NAC or cysteine can cause problems. This often occurs because of or in conjunction with a molybdenum deficiency. Molybdenum or other mineral deficiencies often occur because of MTRR mutations and are often seen in individuals with increased pathogens. A couple examples would be how a chronic Candida infection can lower molybdenum levels or increased sulfur intake can lower molybdenum levels. When molybdenum is low, copper levels often increase and concentrate in macrophages to increase oxidative stress on pathogens. It is all interconnected and the root or base of everything appears to be pathogens.

A potential issue is that the production of glutathione requires so many things that we take for granted. Glutathione can not be made without serine, glycine, ATP, or glutamate. Many of these items are created under an optimal pH and patients with chronic inflammation do not have an optimal pH. Glutamate is a good example. The glutamate/GABA cycle is responsible for ammonia homeostasis and the inflammatory conditions we often face are a very acidic environment. This leads to more ammonia production and as the hydrogen ions get used to convert ammonia to ammonium, that leaves less hydrogen ions that can be utilized. This can create a cellular pH gradient IMO. That is another topic.

I don't advocate eating less animal protein because I want to, I do it because all of my research has pointed in that direction.

Post Edited (Georgia Hunter) : 3/30/2016 4:42:19 AM (GMT-6)

Dr has me on NAC too...........I'll look up why again.

What a puzzel!