for georgia

How do you do this...reducing free radicals?




Posted 9/16/2014 5:39 AM (GMT -6) Quote This PostIgnore Posts From Georgia Hunter.alert An Admin about This Post.


The vector borne diseases often cause oxidative stress and this can cause lesions on neurons. You need to focus on a diet filled with antioxidants and start reducing the free radicals you have been producing.

Sorry Carla, I didn't see this one. I was doing a search and this one came up. Antioxidants, Nitric oxide, and superoxide dis-mutase reduce free radicals. [sic] If we are low on manganese, then the superoxide dis-mutase won't bind free radicals like it is supposed to. If we are low on P5P or any of the B vitamins, that can reduce free radical binding. Our body works like it is supposed to in the beginning, but over time, we lose these nutrients and our diet is not replenishing them.

Here is the problem. We are causing the free radicals on purpose. The harmful free radicals like peroxynitrite and superoxide (just to name two) are caused by us to kill pathogens. Nitric oxide also kills pathogens. The problem occurs when our biological pathways break down from lack of items like biopterin, cobalamin, folate, manganese, magnesium, and sometimes copper. When this happens, our body has too many free radicals floating around and can't stop them because we've run low on these elements. Our body does the only thing it can do to save itself, gene mutation. This down regulates our immune response. That is why epigenetic shifts in CBS, VDR, SOD, MTHFR, and MTRR occur. By doing this, we make less nitric oxide and glutathione (which are both good) but if we can't get rid of the next line of products produced. We end up with more cellular damage from peroxynitrite and superoxide. Supplementing with manganese, copper, etc can cause more oxidative stress because it revs up our pathways but our systems have down regulated and we don't have a system in place to support a revved up immune system. We start making more NO which makes more peroxynitrite and superoxide and we kill more pathogens. We just can't handle the toxins and debris left in their wake. Detoxing is a direct effect of our immune response and when in is down regulated, our detoxing is down regulated.

Someone asked me to explain how something similar on another forum:

"NO acts as an antimicrobial agent. It is one of the reasons why I feel that almost all medical conditions are caused by pathogens and their affect on the body. NO directly effects DNA replication through its by products' deamination of DNA during base pairing. This allows for increased chances for epigenetic shifts and when pathogens are involved, you often see low molecular weight thiols like homocysteine get their levels altered by cystathionine beta synthase mutations and MTHFR mutations. This increases S-nitrosothiols and S-nitrosoglutathione which is often bactericidal. Some pathogens have developed defenses against these actions and other genes are modified by the body in an attempt to decrease parasitemia."

cr3ativegirl said...
[We start making more NO which makes more peroxynitrite and superoxide and we kill more pathogens. We just can't handle the toxins and debris left in their wake. Detoxing is a direct effect of our immune response and when in is down regulated, our detoxing is down regulated.]

Hi, all!

Georgia, Buhner says in Natural treatments for co-nfections that just taking Arginine will actually kill Babesia eventually because it increases NO and they don't like NO. I started taking 750 2x a day for my Babs that recently reared its ugly head. about every 5 days, I am getting a horrible headache in the middle of the night. Is that because of toxin build up? Should I take less? Is it even related, do you think?

thx!

I'd look for dehydration first. Arginine will push the urea cycle which does make more NO, but the problem is that some of these pathogens decrease functioning late in the urea cycle which leads to nitrogen processing problems. That is what I have. Decrease protein intake for a week and see if you still have headaches. The protein combined with decreased urea cycle functioning may be causing ammonia build up.