Traveler said...
isn't cancer caused by oxidation issues? Or is it from methylation issues? I know you go deeper than that with your explanations, but that would help me follow.
Both. I feel that methylation is the single most important pathway in our body. There are many other pathways that are vital, but methylation seems to be more diverse and encompasses so many different components that it effects many of those other pathways.
Cancer is caused by a failure of our immune system to do its job. Pathogens cause our immune system to not do its job. Technically, the polyamines initiate transcript
ion and translation of DNA and cancer is a problem with transcript
ion and translation. Pathogens cause more polyamine production and more methylation and the more you do make, the more chance you have to do it wrong and form cancer.
Here is a quote from a reference and this pretty much says it all.
The polyamines spermidine and spermine, and their precursor putrescine, are required for cell growth and cellular functions. The high levels of tissue polyamines are implicated in carcinogenesis. The major sources of exogenous polyamines are diet and intestinal luminal bacteria in gastrointestinal (GI) tissues.Some notable quotes from this article:
Surprisingly, dietary putrescine also restored intestinal and colonic spermidine pools in NOS2 knockout mice.
This result suggests that colonic luminal bacterial polyamines can contribute significantly to tissue polyamine levels. These quotes mean that a diet high in animal protein will increase polyamine levels in three ways:
1)through eating more polyamines
2)through increased gram negative bacteria in our GI tract that assist in the assimilation of protein (Bilophila, etc).
3)through increased acidity (most protein in animal protein is acidic) The more acid, the less metabolism or breakdown of polyamines. They use a feedback loop and break themselves down but the more acid limits their metabolism. It's interesting to me how most of the protein in nuts, seeds, and vegetables are alkaline.