Feeling worse for how long before switching up abx?

There seems to be as many opinions as people on when to consider a particular treatment (be it abx and/or herbs) to be unsuccessful and to switch to another one. Maybe no longer ineffective could be another term for unsuccessful but curious from the board members when you and/or your LLMD decide to switch things up if you aren't feeling better. The challenge with these infections are, is feeling worse a sign of progress or a sign of ineffectiveness and the bugs are slowly taking over? How do you even tell the difference sometimes as you hear some things can take weeks to take effect? Thanks for any replies.

Unfortunately detoxing does little to nothing for me so hard to gauge. The way I'm looking at it, if I feel like garbage more and more consistently I"m assuming the regimen I'm on is losing its effectiveness. This kind of happened with Rifampin around the 4 month mark. I think I'm going through the same thing on Bactrim after about 2 months.