I took mine full dose to start with, and I also mixed herbs, but maybe that is why my liver enzymes are high, too much too fast. The herbs are supposed to be synergistic from the reading I've read. I integrated herbs in this order:
Cats Claw
JN
a few months
then integrated a bunch of other stuff, one or two herbs at a time.
If you haven't invested in Buhner's books, I'd highly recommend this.
Here he answers a question about
combining tinctures.
buhnerhealinglyme.com/basics/combining-tinctures/