first visit with LLMD- flucanzole?

just met with new LLMD yesterday...he uses pulsing 2 wks on 2 wks off

for first 2 wks im just using tetracycline....after 2 wks off, i will add flucanazole to it, not for the purpose of being an anti-fungal, but rather to fight the lyme...the LLMD said they have had some good results with it...

from reading the forum archives, it seems like this idea of using it against lyme has been around for awhile, but does anyone have any experience with it? a number of past posters expressed their herxing on it, which others dismissed as being candida herxes...my LLMD expressed that it was effective in neuro... any thoughts/opinions?

No experience with it, listening and caring, grateful you are connected to an LLMD. Got your detox plans underway?

Shopping list
my favs
Lemons - put in H20
Bragg's Apple cider vinegar - put in H20, around a tablespoon
Charcoal tabs, or another binder like chlorella - 2 hours before after you have eaten and 2 hours before you are going to eat again
epsom salt - foot soak or a bath
dry brushing
sauna at the gym if you have energy and have access
massage - if you have the $$
http://www.tiredoflyme.com/detox-methods.html

Despite what you may have read or what your physician has told you, fluconazole does not kill the Borrelia strain of bacteria. I could go into the specifics of why it does not kill those bacteria but I'm going to keep this understandable. We need to go a step farther in this situation and look at what is happening. Does fluconazole often help Lyme patients? Yes it does. If it doesn't kill Borrelia bacteria but helps with Lyme, how is it working? It works exactly like it is supposed to work, it kills fungal infections. When you reduce your fungal pathogen load, that frees up your immune response (which is maxed out killing the most accessible pathogen) to kill less accessible pathogens which are Borrelia bacteria. Borrelia is a crafty little joker in that it can be just about anywhere in the body. In the blood, most Borrelia is easy to kill (except for the morphing forms). Not all Borrelia morphs into L-forms or cysts. But the Borrelia that lives in the extracellular matrix is more difficult to kill because the immune system can't get to it very well. This is why stretching and light exercise help so well in treating Lyme. They increase our immune response's ability to get to the extracellular matrix.

I prefer to pulse fluconazole about twice a week. It works rather quickly in reducing fungal loads and twice a week is often sufficient enough to keep fungal levels down.

Mustard Seed said...

Very much agreed, though there is some evidence that Diflucan might be able to kill cysts:

www.mdpi.com/2079-6382/4/3/397/htm

According to that research, almost all those antibiotics help to kill stationary Borrelia. That's a good thing. Unless Borrelia utilizes ergosterol in cell walls like the fungi, I see no plausible method of action for fluconazole to help eradicate Borrelia. I haven't seen that in the literature but I'm still looking.

I have experience with Fluconazole (Diflucan) as I took it for 6 months with other antifungals.

At the time I believed I was only dealing with a systemic yeast infection.

I believe a combination of Itraconazole, Terbinafine, and Fluconazole (at different times not all at once) saved sight in my left eye. Itraconazole was very difficult to tolerate. I lasted 11days and needed 12 off to repair as I think it was leading to congestive heart failure.

Fluconazole was tough after a week and I had to take a break for a week before resuming mainly due to kidney fatigue.

Eyes didn't go from red to white until I added Doxy but a month of Doxy is all I could tolerate (kidney fatigue). I am glad I stopped Doxy because I believe it is risky as a monotherapy and others confirm this. There is an NCBI study that states Doxy and Fluconazole may be synergistic.

There may still be issues going on in my eye but nothing like before and it is much improved. I don't feel a foreign object feeling anymore.

Once again I find myself in agreement with +Georgia Hunter 's assessment.

I just completed reading the new Savely Morgellons E book that is free on kindle for the remainder of the day at the link below. The book also agrees.

www.amazon.com/Morgellons-legitimization-disease-Factual-Clinical-ebook/dp/B01MG9BEK4/ref=sr_1_1?s=digital-text&ie=UTF8&qid=1480871807&sr=1-1&keywords=morgellons

Post Edited (ChickenArise) : 12/4/2016 10:35:25 AM (GMT-7)

Mustard Seed said...
And these medications are being tested in a test tube, not in the human body of course.

If you call 11 patients with neuro lyme "test tubes" then so be it.
/www.ncbi.nlm.nih.gov/pubmed/15337633

dbwilco said...
http://www.lymenet.nl/forum/viewtopic.php?t=595

here is where the lyme aspect comes from- German dr who utilized it to kill neurolyme supposedly

"JN: Tell me your reasoning as to why diflucan might work in chronic lyme.
FS: There are several reasons. First of all, it inhibits an enzyme called cytochrome P450. This is an enzyme that your liver, for instance, uses to detoxify chemicals and drugs. Borrelia has a very primitive p450 defense, so if you inhibit it, it is easily weakened. Therefore I believe that diflucan inhibits the growth and replication of borrelia. It does not necessarily kill it. In addition, it penetrates well into the cells and into the nervous system and brain, where borrelia may hide. "

Thanks for the post. I will need to read more about this before I can get on board with it. Cytochrome P450's are proteins and there are many dozens of them in the body. They couple with other proteins to reduce the iron in their structure. We know that borrelia doesn't utilize iron. It would have to be a specific P450 protein and one would think that would be fairly easy to evaluate in studies. I'll certainly look into this.

dbwilco said...
thanks Georgia- i greatly respect your opinion...the German dr does say it doesnt neccesarily kill it, but my LLMD (who is well known former ILADS officer) said that he finds it very useful, especially in lyme in the brain, which i would assume is not a location of candida...anecdotally alot of posters in the past talked about major herxes related to the diflucan, which most ascribed to candida, or a lessened candida presence allowing lyme killing...i dont start it till next month, but I'm hopeful/intrigued

Let us know how it turns out. Diflucan helps no doubt in my mind, just the mechanism how it helps is what I question. IMO, the in vitro studies should show more activity against Borrelia if it had a direct mechanism of action.