Western Blot Questions..

These tests are wildly inaccurate. But, if you're symptomatic and testing positive 23/41, you might want to start treating.

IGG/M doesn't really help much. I throw them both all the time, does it mean I'm re-infected or just that there is a growth uptick?

Tick - IgM means Active infection, IgG means older infection, but can also be active.

In most diseases - IgM is the first to show up, and then after a few weeks, it converts over to IgG.
This isn't always the case with Lyme.

The IgM antibodies can continue to show up for months, even years.

This is from Dr. Jemsek's website:
"In virtually all infections, the IgM class of antibody (immunoglobulin) appears first and therefore represents a marker for an early infection. In most immune models, the IgM antibody gives way to the well-known IgG antibody class, usually regarded as the major enduring antibody response in chronic infectious diseases or other immune models. In almost all infection models, after just a few weeks, the IgM antibody level wanes to the point of being non-detectable and does not recur. However, a confounding fact in Bb infections is that the IgM antibody may persist for years, a very unusual situation in most disease states. Logically, one would have to conclude that this reflects an ongoing reactivation or persisting and continually renewing infectious state of Bb infection. Most active diagnostic laboratories involved with LD tend to agree with this notion. "


I had symptoms for 15 months and my IgM was positive.