Daptomycin??

Has anyone here used abx Daptomycin?
I believe it needs to be injected (vs oral use).

I read a study by Dr. Zhang from Hopkins that looked promising regarding use of Daptomycin (alongside other abx such as Doxy). It appears to be effective against persister B.b.

Anyone here has expierence with this drug - please respond...

Do you have a doc that will script it ?...and the other 2 abx no body likes being first ...dr h like dapsone but its oral leprosy drug not dapto iv ...
curza is supposda pass phase 3 trials this year ..and there is the anabuse drug too...will you try it and let us know how it goes ?

bump

bmoberg337, did you try Dapto combination in continous infusion??

In Vitro, Dapto loses its efficacy with pulse dosing and I think 30 minutes infusion (how this drug is usually prescribed) will work like pulse dosing.

Maybe the only way to receive such drug combination would be hospitalization or using an OPAT device.

https://www.ncbi.nlm.nih.gov/pubmed/27867375

Front Microbiol. 2016 Nov 4;7:1744. eCollection 2016.

Ceftriaxone Pulse Dosing Fails to Eradicate Biofilm-Like Microcolony B. burgdorferi Persisters Which Are Sterilized by Daptomycin/ Doxycycline/Cefuroxime without Pulse Dosing.

Feng J1, Zhang S1, Shi W1, Zhang Y1.

"Importantly, we demonstrate that pulse dosing treatment impaired the activity of the persister drug daptomycin and its drug combination against B. burgdorferi persisters and that the most effective way to kill the more resistant biofilm-like microcolonies is the daptomycin/doxycycline/ceftriaxone triple drug combination without pulse dosing."

Welcome to our community, guirmg!

Since you are new here, it would be helpful for you to read through the thread at the top of the page titled: "new to Lyme?..Start here!" It's packed full of useful information.

This is a great community - lots of knowledge and support here.

Please feel free to share your 'story' with us.

bmoberg337,

I think that 2 hours infusion qualifies as pulse dosing. It means that the antibiotics will have a very high concentration (and above the MIC - minimum inibitory concentration) during the infusion but some time latter, the antibiotics will be metabolized and you will have low concentrations, bellow the MIC, during a long part of the day until the next infusion, which can make the combination loses its efficacy, as showed in the article.

Remember this is IN VITRO data and they are doing tests in animals to confirm that. But, if I would try it in myself, I think it should be important to mantain the antibiotics level close to the MIC during a longer period of time and the best way to do it should be in continous infusion.

Daptomycin pharmacokinets is very linear - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC152488/
and maybe the same dose used in 30 minutes infusion can be done in continous infusion to reach the MIC concentrations in blood. But, unfortunatly, I don't find any information about of Daptomycin blood concentrations in continous infusion, I don't know if there are tests avaiable to measure that and the dose for continous infusion can be different.

Thanks for the welcome, Girlie! My story with Lyme disease started in October 2016. I'm physician (Radiation Oncologist) and I live in Brazil. In Brazil we don't have Ixodes ticks, so the disease is very rare, and it is transmited by another kind of ticks. As we don't have competent vectors here (Ixodes), the Borrelia burgdorferi is different from the US (more resistent, persistent, uncultivable) and the disease here is called Lyme-Like disease. To me, the Brazilian Borreliosis is a kind of proof of concept of the importance of the Borrelia persistence in Lyme disease in humans and I think this antibiotics combination can help a lot of people in the future, but we still don't know how is the best way to use it.

Sorry for any language mistakes.