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Lyme and CD57

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Posted 1/30/2017 8:22 PM (GMT 0)
Hello, All -

I am a bit confused about some conflicting test results I have and would appreciate any experience or insight that you can share.

I've had a series of three lyme tests from a standard lab over the last five months:

All three ELIAS tests have been positive at 1:28, 1:51 and 1:33.

All three Western Blot tests have had the same results:

IgG positive for bands 23, 39, and 42.

IgM positive for band 23.

I have also tested positive Babesia Microti IgG 1.80.

However, I was just tested for CD57, and the result was "normal": 147 on a reference range of 60-360.

Isn't the CD57 result inconsistent with the Lyme tests results?

Again, would appreciate any insight.

Invictus67
Posted 1/30/2017 8:34 PM (GMT 0)
CD57 shows that your immune system is not working properly, that its function is reduced. Your CD57 is normal, which shows that your immune system is working. I think this shows you will be able to heal faster.
Posted 1/30/2017 8:46 PM (GMT 0)
Thanks, blueberrymuffin.

I certainly hope that it's the case that I heal faster, but, so far, that doesn't seem to be the case. I was on Doxy for 90 days and many of my symptoms got better. At the end of the 90 day Doxy, my muscles started twitching all over constantly.

An LLMD then put me on a three-antibiotic protocol, with lots of supplements, and that continued for six weeks.

This morning I started on a protocol of Mepron, Minocin, Omnicef and Artemisinine.

I guess I am questioning the CD57 because of the concern that my twitching is something other than Lyme.
Posted 1/30/2017 9:01 PM (GMT 0)
Yay for your cd57 number. Had mine tested recently and my number had climbed to 138.

Some doctors say treatment can be discontinued at 150, assuming immune system will erradicate any remaining crap

Others say after 2 months of no symptoms.

And still others say the number means nothing.

I'll go with #2 😉
Posted 1/30/2017 9:43 PM (GMT 0)
You may need to look into Bartonella...after you've given Babesia a fair run at treatment.


Many LLMD's don't run the CD57 - because of it's inconsistency...as it was in your case.
With those Lyme test results...there's no questioning you have lyme disease.

I wouldn't use the CD57 to dictate when to stop treatment...unless the person is already symptom free.

I also haven't heard that you will heal faster if the CD57 is in normal range.
Posted 1/30/2017 11:19 PM (GMT 0)
Purrsiankitty: Thanks for your thoughts and congratulations on your increasing CD57. I'll keep my fingers crossed for more progress.

Girlie: Appreciate you pointing me toward Bartonella. I believe I had the rash (but didn't recognize it as such at the time), and my primary remaining symptoms are the muscle twitching -- driving me absolutely -- and migrating muscle aches.

A recent test also showed Low T and DHEA- Sulfate. I wonder if those are related to Bart too?
Posted 1/31/2017 1:59 AM (GMT 0)
Low T - as in Testosterone?

Well, I had low DHEA....and low estrogen. Can't remember my testosterone.
I'm female...though.

I know lyme/bart messes with our hormones.

I'm pretty sure mine was from Bartonella..
Posted 1/31/2017 2:11 AM (GMT 0)
CD 57 can be low, normal, or high with lyme.

CD57 is just a "possible" indicator. This mean if it is low then it is an indicator of Lyme, because it has been scientifically proven that Lyme has the ability to lower this. It is the only scientifically proven/known pathogen that can make it low, HOWEVER the science also admits there's always a chance it can be something else, but not that they know of as of now.

So basically if it's normal or high, it's a useless indicator when trying to determine lyme (assuming other results didn't show lyme), BUT if its low it can be a strong indicator of lyme. It kind of works in one direction only to have any meaning.
Posted 1/31/2017 1:27 PM (GMT 0)
1000Daisies: The test was through LabCorp and ordered by a LLMD in the DC area.

There were no tests in this round for Lyme or Co-Infections; just the basic liver function tests with a few "specials" thrown in like the CD57. The abnormalities were my Testosterone (low) and DHEA (low) and a gene mutation: a1298c homozygous.
Posted 1/31/2017 2:22 PM (GMT 0)
The thing is that it's not known what all affects the numbers on the CD57. So saying that when you reach a certain level, you can stop treatment is a little like Russian roulette. You are taking very high chances that you still have too much bacteria in your body for the immune function to handle, so the person risk a fairly high chance at a relapse.

Unless someone has seen new research showing something different, these articles will explain it much better than I can:
/www.researchednutritionals.com/library/lyme/everything-you-wanted-to-know-about-cd57/

lymemd.blogspot.com/2009/01/cd57.html
Posted 1/31/2017 5:26 PM (GMT 0)

Traveler said...
The thing is that it's not known what all affects the numbers on the CD57. So saying that when you reach a certain level, you can stop treatment is a little like Russian roulette. You are taking very high chances that you still have too much bacteria in your body for the immune function to handle, so the person risk a fairly high chance at a relapse.

Unless someone has seen new research showing something different, these articles will explain it much better than I can:
/www.researchednutritionals.com/library/lyme/everything-you-wanted-to-know-about-cd57/

lymemd.blogspot.com/2009/01/cd57.html

. Crap, that link isn't working. I was looking forward to reading it.
Posted 1/31/2017 6:13 PM (GMT 0)
I get so disgusted with sites that don't want their articles linked to!! Sorry!! Here's another option. Same article, same author:

www.lymebook.com/CD57-test.pdf
Posted 1/31/2017 10:38 PM (GMT 0)
😀
Posted 2/1/2017 12:14 AM (GMT 0)
Traveler is correct, even if your CD 57 is high you can definitely have/still have lyme. The test only really tells you something/have any meaning if it's really low.

However it is good sign if it's high because it means good immune health (in that area). So the test is definitely worth taking and monitoring. But same can be said with all immune, blood, and organ health test.
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