gfields said...
What is the story with insulin resistance? Maybe that is what I had. Is that diabetes? Or problems with the kidney?
Insulin resistance is a precursor to metabolic syndrome. It is not in and of itself diabetes but can lead to it. When you have an infection/trauma your body develops insulin resistance as a mechanism to preserve glucose and modulate whole body metabolism so that cells that need glucose to produce NADPH (immune cells, damaged cells) for rapid division and redox functions have priority access. Insulin encourages glucose uptake by cells with insulin receptors so this basically restricts access by making cells insensitive to it. The alternative is protein catabolism => muscle wasting => death and is used as a last resort when the body has depleted it's glucose stores. You can't make NADPH with stored fats which is why this system is in place. This is not the standard understanding you'll get. Most docs consider it deleterious to be reduced at all costs... But it serves a purpose. You'll often hear people say that cancer loves sugar or talk about
warburg metabolism as some mysterious anomaly. So the corollary to insulin resistance is that rapidly dividing cells (like cancer/wounds/immune cells) produce their NADPH and then form lactic acid which can be recycled by the body to glucose (how altruistic of cancer... *cough* it's just a wound *cough* a parasite infested wound* ugh). It's all about
saving glucose despite needing to use more of it and minimizing protein catabolism. Extending the bodies resources to fight infection and repair trauma when the organism is too injured/sick to acquire new calories. Anyways, how insulin resistance leads to diabetes is when the pancreatic cells can't secrete enough insulin to overcome it so glucose builds up in the blood and basically sticks to a bunch of proteins and ruins them. So there are a mix of things that go into that such as high sugar diets that didn't exist eons ago when this system formed as well as inflammatory damage to the pancreas that decreases its capacity to produce insulin. But to be honest I don't know all that much about
the specifics of diabetes and my memory of this is slightly hazy.
Anyways you can check for diabetes/prediabetes, kidney and liver function on basic lab tests. If you're having unusual symptoms i would keep up with a doc for labs. I had a lot of similar things and they all came back normal