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Surviving Mepron -- Any Tips?

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Posted 4/28/2017 6:15 PM (GMT 0)
Hi,

I have been taking Mepron and Zith for Babesia for the last 16 days (yes, I'm counting). I was on Zith previously, and have tolerated it well. I initially thought Mepron was a breeze, but at about the one week mark, I had GI distress (stomach cramps/diarrhea) for a couple of days.

Now, over two weeks in, I have daily nausea. It starts about an hour after my morning dose and then subsides just in time for me to take my evening dose.

Has anyone been able to get past this? What has worked for you? My LLMD would like me to be on this for several months (and add Bactrim to the mix for Bart). Does taking Mepron with fat help alleviate the nausea or is it simply a tool for better absorption? I am open to any ideas.

Thanks!
Posted 4/28/2017 6:31 PM (GMT 0)
I haven't experienced nausea with the Mepron.

I did have some diarrhea - that I thought was from the Xylitol....still not sure ...but I don't have it anymore.

I am pulsing my Mepron though.

So you're not taking it with fat? You need to. I take 1 Tbsp of peanut butter, plus 1 Tbsp of coconut oil...and then eat my breakfast or dinner.
Posted 4/28/2017 6:39 PM (GMT 0)
I'm taking it with some fat, but it's probably not enough, and it's just related to whatever I'm eating for breakfast or dinner. Nothing as concentrated as peanut butter. Will try that. Thanks.
Posted 4/28/2017 7:17 PM (GMT 0)
yes, try specifically taking concentrated fat with it.

I didn't have problems with mepron (other than herxing) except after my evening dose with zithromax. The two together made me hugely bloated. I took my Mepron and fat with dinner and my Amoxy, then waited one hour and took the zithromax. Bloating gone.
Posted 4/28/2017 7:19 PM (GMT 0)
I lied - for the first two weeks it made my tongue and lips numb! But that went away, and my doc never heard of it happeneing to anyone else!
Posted 4/28/2017 7:25 PM (GMT 0)

BabsBunny said...
I lied - for the first two weeks it made my tongue and lips numb! But that went away, and my doc never heard of it happeneing to anyone else!

LOL - I have done that - said something...and then remembered after that what I said wasn't correct ..it's not a lie - you just forgot!!!
Posted 4/28/2017 7:30 PM (GMT 0)
BabsBunny, you won't believe this. But, I had an issue with my tongue (front half) going numb this week! OMG. My LLMD said, "hmm, I'm not worried, but keep me posted." It went away after a few days, but not before it affected my lips. You're apparently not the only one!
Posted 4/28/2017 8:00 PM (GMT 0)

KB69 said...
Hi,

I have been taking Mepron and Zith for Babesia for the last 16 days (yes, I'm counting). I was on Zith previously, and have tolerated it well. I initially thought Mepron was a breeze, but at about the one week mark, I had GI distress (stomach cramps/diarrhea) for a couple of days.

Now, over two weeks in, I have daily nausea. It starts about an hour after my morning dose and then subsides just in time for me to take my evening dose.

Has anyone been able to get past this? What has worked for you? My LLMD would like me to be on this for several months (and add Bactrim to the mix for Bart). Does taking Mepron with fat help alleviate the nausea or is it simply a tool for better absorption? I am open to any ideas.

Thanks!

I had some slight upset stomach on Mepron, about an hour after taking it. Nothing significant. It went away after 2 weeks.

When I had stomach issues with other antibiotics, my LLMD recommended ginger root. Might want to try that.
Posted 4/28/2017 8:11 PM (GMT 0)
I lick the spoon of all the mepron after taking a dose (i know gross) and it turns my tongue a bit numb so its absolutely something that it causes if you let it sit on your tongue like that.

following ILADS guidelines Bactrim is typically added to Zithro/Mepron if Babesia is being stubborn. It also can hit Bartonella and while I've heard some have made solid strides with treating Bartonella for most it isn't enough. Still it treat Babs and will hit some Bart and also has action against Lyme so it's a pretty good drug to work into your regimen.
Posted 4/28/2017 8:24 PM (GMT 0)
I lick the spoon too...just to get every last bit of it. I'm starting to dislike the taste though....it could get to the point of gagging.
I've always had really sensitive taste buds...and a really strong gag reflex.

I don't know how long to give the Mepron at the 1 tsp dose before knowing it's being ineffective and raising the dose. I'm certainly 'feeling ' it...so maybe that's a good enough indicator that it's working.

I'll finish up this round and see where I'm at on my off week.
Posted 4/29/2017 2:09 AM (GMT 0)

Rikky1 said...
I lick the spoon of all the mepron after taking a dose (i know gross) and it turns my tongue a bit numb so its absolutely something that it causes if you let it sit on your tongue like that..

aha! I knew i couldn't be the only one! yes, i was in the habitat of licking the spoon (no dosing method works because of the thickness, so you just have to use a regular spoon) but when I got used to it, i put it as far back on my tongue as i could and tried to keep it away from my lips.

Speaking of spoons, no matter how many times i checked the capacity of my teaspoons, the bottle of Mepron didn't last me 3 weeks like it was supposed to. So i either filled the spoon too full or most of it got stuck in the bottle. I put it in a glass upside down for 3 hours and not even a drop came out smile)) insanely thick stuff!
Posted 4/29/2017 3:21 AM (GMT 0)
BabsBunny - Are you using a measuring spoon or just a regular spoon?

I'm still on my first bottle - but I am pulsing - I've taken 18 days at a tsp twice daily. Not sure how many more days I will get out of the bottle. I will update in a few days.
Posted 4/29/2017 11:32 PM (GMT 0)
I took a measuring spoon (tsp) and poured water from it into a kitchen spoon, and it was full- so I assumed my kitchen spoons were 1 tsp. So I used them. But Mepron is thicker, so maybe it piled up more than a tsp? Everything else I tried got stuck, and the syringe didn't fit in my bottle. Even my measuring spoons were so deep that i had to lick it out or use my finger, which made my tongue numb and / or stained my lips and fingers.
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