10LymeB said...
Can anyone share their experiences on Lithium Orotate and Puerarin? These are two new supplements my LLMD wants me on. I'm not sure about either. I know Puerarin is kudzu, right? As for the Lithium Orotate, I'm not sure I want to be on any kind of mood lifter on a regular basis. I really want my body to start doing it on its own.
When we have Lyme, there are so many biological pathways in our body that become much less efficient because we lack the elements, nutrients, or vitamins we need for the reaction to occur. When this happens, the body struggles to find the catalysts and substrates needed for the reaction to occur. It uses alternate substrates and the pathway can continue but with much less efficiency. Lithium is one of the elements that becomes depleted. It is used in and around the mitochondria (blocks the phosphorylation of GSK3) and it ultimately helps reduce oxidative stress in the mitochondria. Over the counter lithium comes in 5mg, 10mg, and 120mg. I like to use the lowest dose that works for anything so I like the 5mg. I wouldn't worry about
taking such a low dose as the prescript
ion strength of lithium is usually 300mg taken multiple times a day. There is even a 450mg extended release prescript
ion strength.
Other than replenishing depleted lithium stores, decreasing insulin spikes would be beneficial as that would reduce GSK3's effects. GSK3 does many things inside our cells but over expression of it causes problems when we have Lyme. Eating 5 or 6 small meals a day would be beneficial in reducing oxidative stress. Eating fewer carbohydrates with a high glycemic index would be helpful. IMO, eating more alkaline foods would be helpful.
Just a FYI, but Tryptophan uptake is the limiting factor in serotonin synthesis. It is believed that low doses of lithium reduce the degree at which Tryptophan uptake is the limiting factor in the regulation of serotonin synthesis. In a nutshell, if you are depressed, low doses of lithium may help.