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Posted 8/30/2017 1:32 AM (GMT 0)
Hi,

I just went for my third appt with LLMD and he added in diflucan in addition to omnicef. Should I expect a herx? Anyone have experience with diflucan?

Thanks!
Posted 8/30/2017 1:40 AM (GMT 0)
I didn't herx on it - have only taken it once - I did a week of it.

The omnicef is new too?

Be prepared to herx on that.
(Some people report they herx from Candida dieoff when taking Diflucan but I didn't)
Posted 8/30/2017 1:49 AM (GMT 0)
The omnicef I have been on for two months, so that's not new and boy did I herx on that. I will wait and see with diflucan!
Posted 8/30/2017 11:22 AM (GMT 0)
Diflucan is used for systemic candida, and yes candida die-off can cause a similar reaction to a lyme herx. Some also say that Diflucan is also a mild cyst buster, which can also trigger a lyme herx. Diflucan is also tough on the liver so watch your AST ALT levels.

I've used it frequently through my treatment. I never experienced any major die-off reaction. My LLMD just rotates it into my protocol periodically to control candida. I've also taken nystatin long term that targets candida in the gut. I try to rotate diflucan, nystatin, and more frequently NOW brand Candida support to keep Candida in check. It's good to change up now and then to keep Candida from building resistance to either one.

Post Edited (tickbite666) : 8/30/2017 5:25:38 AM (GMT-6)

Posted 8/30/2017 10:06 PM (GMT 0)
diflucan made me herx badly. i took it for only 3 days but starting day 2 it was almost unbearable. this probably was candida herx because i was going off antibiotics after 6 months of rotating through many types....

then again diflucan does kill borrelia quite nicely, and it does get to the brain in almost 100% , so .... good brain borrelia drug. however it is very toxic to the liver, so not sure if it's a good idea to take it for too long....
Posted 8/30/2017 10:18 PM (GMT 0)
mpost - isn't diflucan an anti-fungal - are you saying it has antibacterial properties as well?
Posted 8/31/2017 6:21 AM (GMT 0)

Girlie said...
mpost - isn't diflucan an anti-fungal - are you saying it has antibacterial properties as well?

it is not only antibacterial, it is anti persister on the same level with daptomycin, see Table 1 in link below, it's among top 10 hits (Table 2)

www.mdpi.com/2079-6382/4/3/397/htm

A big advantage of diflucan as anti-borrelia is it crosses the BBB in concentrations above 90%, so basically it does not get stopped by the BBB at all.

"The maximum blood drug concentrations (Cmax) of several active hits, including 3-formyl rifamycin, oltipraz, and fluconazole, were higher than the MICs of these drug candidates, indicating these drugs are likely to achieve clinically relevant drug concentrations. "

The problem with diflucan/fluconazole is as i said, liver... very toxic.

But the point is there are MANY incoming treatments for people with persisting symptoms, this research was published late 2015. Nobody knew about diflucan as anti borrelia drug before. Hell, nobody knew Borrelia has persisters in the scientific community before 2015. Yes LLMDs had a hunch, but this was just "lessons from the field" not consistent lab findings.

Now everybody is searching for antipersister drugs for it...A lot of hope ahead.
Posted 8/31/2017 7:13 PM (GMT 0)
Since May I've been pulsing 1500mg Tetra, Alinia, and Diflucan. I just restarted on Monday after a 3 week break. Today I'm dragging my butt.
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