girlie sorry maybe i was a bit too harsh. but look, now the paper by k. lewis i mentioned earlier is acess free and we can quote:
"Nitroaromatic compounds such as metronidazole are prodrugs that are converted into reactive drugs by bacterial nitroreductases. These enzymes are expressed under anaerobic or microaerophilic conditions and target pathogens living in these environments (i.e., Helicobacter pylori, Clostridium difficile, and E. coli). We found that some nitroaromatic compounds, like nitrofurantoin, are effective in killing E. coli persisters (45). However, we did not detect homologs of nitroreductases in the genome of B. burgdorferi. The MIC for nitroaromatic compounds (nitrofurantoin, nitrofurazone, and metronidazole) was too high to make them useful agents for killing B. burgdorferi persisters (data not shown)."
this is from an earlier study by e. sapi
"Tigecycline and tinidazole treatment reduced both spirochetal and round body forms by ∼80%–90%. When quantitative effects on biofilm-like colonies were evaluated, the five antibiotics reduced formation of these colonies by only 30%–55%"
so not only nitromidazoles drugs dont work, they are not even supposed to work because borrelia lacks the chemical these drugs use to bind and become deadly....
i personally took tinidazole 1.5 grams per day for 5 months , combined with 2 other antibiotics in copious doses (mino, cipro, doxy, rifampin, etc) and im still sick. i am aware that this is at least 500mg higher than what most of u have tried...
all the studies that i have seen say they are not working on persisters, yet almost everybody here on the forum took them to some extent and we advertise them as cyst busters. even i did that many times here
by "garbage" i mean ineffective. some people are just lucky and with a bit of help from the abx they recover temporarily. i dont think they get cured and u hear back from them 5+ years later when they had surgery or took steroids and relapsed.
some believe they were reinfected just so that they are let to believe they won the first fight and now they have another challenge, when i suspect in most cases it's the same infection they had in the first place.... i keep remembering that mouse study where they "cured" a mouse of lyme but continued the study. 9 months later the mouse had lyme again, after a good period of being asympyomatic.... in disbelief, the researchers tested to see if this was the same strain of borrelia or they had the DNA a bit different, showing the mouse was maybe reinfected. their findings showed it was the exact same strain used the year before to infect the mouse....
sure thing i believe we all should take our lyme meds as this is the only way to keep the infection in check. yet our treatments involve 100+ pills a day, and no success story at the end of the line, you only can hope for a draw.... there should be NO REASON for us to be satisfied with this outcome. 12 infections per person? one being borrelia and the other 11 opportunistic? and we need to treat all 12? give me a break...this is not good work. for HIV patients they administer antivirals, the virus is suppressed 99.9%, the immune system recovers and all these so called coifections (which AIDS people, boy, they know a lot about
, and for good reason, they were killing them) are slowly put to respect. u cant get cured of candida in no beter way u can get cured of lactobacillus. it is part of your being. but candida is sometimes deadly for untreated AIDS.
im upset because all this lyme disease is approached from a very wrong angle, the source of misery is the lyme persisters which make us immune defficient.
98% of humans have CMV, 90% have EBV, 20% bartonella and if u have a pet that number is 50%....there is no wonder we lymies look like crazy when we enter our GP practice and say "doc i have 10-12 coinfections i have CMV and EBV and many others, i am very sick" the doc will know that's nonsense, some will even demand u test for HIV... and it's part of the problem with people thinking us lyme folks are nuts or prey to fringe doctors ...
we dont have 12 coinfections we have an immune defficiency syndrome caused by one infection that supresses the immune system and is invulnerable to all antibiotics we now have.... let's ask for more funds, more research on THAT.
and when doctors that are not lyme literate ask, we need to raise awareness of these findings, that we have a "softer AIDS", not 12 coinfections, that makes us look silly, especially good doctors that know all these infections are harmless in immunocompetent people....