Agmatine Sulfate supplement can reduce your tolerance to opiate and opiate like pain medicine (Kratom).
I recently found Kratom was not working effectively as my tolerance required doses to increase over time from 8g to 15g per dose. When my third and or fourth dose of Kratom at 15g was not working anymore, I switched to Oxycontin and Ibuprofren for 7 days. On the 8th day it was time to switch back to Kratom.
I started the day with Agmatine Sulfate 1760mg on an empty stomach in the morning. Ceasing all Oxycontin intake I resumed Kratom therapy at just 8g per dose one half hour later. I has been 2 days and the Kratom is working again at this lowered dose. I take at least one additional 890mg dose of Agmatine later that day, on the second day (and every second day) this becomes two doses for an additional 1760mg.
I am pleasantly surprised. More related information and references below for those interested:
Effects of agmatine on tolerance to and substance dependence on morphine in mice.
/www.ncbi.nlm.nih.gov/pubmed/10452098Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury
/www.ncbi.nlm.nih.gov/pmc/articles/PMC27068/
How to take Agmatine
www.supplementcritic.com/agmatine/Agmatine is a metabolite of L-Arginine, but acts very differently. Do not take with L-Arganine.
Also dont take Agmatine with Yohimbe since Yohimbe deactivates the a2 adreneric receptors, whereas Agmatine activates/binds to that same receptor.
It shows promise for alleviating neuropathic pain and drug addiction but without opiate use has been known to increase perceived pain. Agmatine supplementation can also protect from strokes and benefit cognitive health.
/examine.com/supplements/agmatine/