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igm not converting to igg

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Posted 12/9/2018 4:50 PM (GMT 0)
Wondering if anyone else here has had a positive western blot or immunoblot igm that has not converted to igg?

In the spring of 2017 I had a positive WB igm. The igm is still positive yet the igg is negative. Ideas?
Posted 12/9/2018 5:09 PM (GMT 0)
I haven’t retested so I don’t know.

I tested IgM positive after 14 months of symptoms tho.

You do know that with Lyme IgM often stays positive.?

Dr J wrote that it may be a continual reactivation of the infection (or something like that)

You are still symptomatic?
Posted 12/9/2018 6:20 PM (GMT 0)
Thank you, Girlie.
Yes, I have heard the igm can remain positive but wonder why it does not convert. Suppose it could still be an active infection. My symptoms are greatly reduced. I have noticed some increased fatigue lately, though.
In addition to the positive igm, my CD57 has tanked again and is down to 38. It was up to 70 a few months ago.
Tomorrow I have an appt w/llmd. Perhaps I will learn more then.
Thanks again.
Posted 12/9/2018 6:38 PM (GMT 0)
Immunologists like Monica Embers and Nicole Baumgarth have done research showing that antibody responses are highly variable when it comes to borrelia. Some people mount chronic IGM responses, others have no response at all... I think it has to do with the dysfunction borrelia causes in the immune system.
Posted 12/9/2018 6:39 PM (GMT 0)

mareish said...
Thank you, Girlie.
Yes, I have heard the igm can remain positive but wonder why it does not convert. Suppose it could still be an active infection. My symptoms are greatly reduced. I have noticed some increased fatigue lately, though.
In addition to the positive igm, my CD57 has tanked again and is down to 38. It was up to 70 a few months ago.
Tomorrow I have an appt w/llmd. Perhaps I will learn more then.
Thanks again.

Well if you're symptoms are reduced but not gone...then it's likely that you have active infection.

Have you stopped treatment?
Posted 12/9/2018 6:54 PM (GMT 0)
Yes, I stopped treatment at the end of April, at the surgeon's request, when I had a mastectomy and have not resumed. I had been on a number of different antibiotics for a little over a year and they helped tremendously. Guess I may be going back on them.
Appreciate your replies.
Posted 12/10/2018 12:57 AM (GMT 0)
Thank you, Rainy Cloud. The article is quite helpful.
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