https://academic.oup.com/jac/article-abstract/3/3/239/683625?redirectedfrom=fulltextTini penetrates the BBB, therefore it is killing lyme spiro's in the brain and that is likely giving you a headache.
Have you tried taking some glutathione caps? Also try a supplement called Alphasorb C, really good for brain herxes (but dont take it if you have mercury fillings in your mouth). magnesium and potassium also important