Neuro Pain cream - absorption into blood stream an issue?

Those are some heavy-hitting ingredients! I understand your concern. Personally, I would try a topical cream before an oral drug any day. The effects should be much more targeted than if it went through your digestive tract, and orals have to be high enough doses to pass through your whole body to reach the painful area. I don't know about this specific cream, but if I had a tube handy, I would be trying it out today. ;)