Hyper sensitive to treatment

Hello All! I have been a “passive” participant in this community for quite some time and have found all of your input invaluable. I decided to become active as I am in need of some advice. To make a long story short, I was diagnosed with Late Stage Lyme only a year ago but fell incredibly ill in 2013. Lyme and Babesia were found in urine per DNA Connexions but not in bloodstream per igenex. Aperiomics found mycobacterium which I assume is mycoplasma. The illness is everywhere...symptoms include bone pain, joint pain, neuro issues, etc.


When my LLMD put me on a full dose of rifampin and Mino and a pulsed dose of Alinia (3 days every 2 weeks) I went into hyper Herx - my brain felt as if it was shutterring and my hands and feet were curling up. Epsom salt baths, binders,Magnesiumm, lemon water did not help. I kept having to back off the meds as I couldn’t tolerate more than 4 or 5 days.

My doc gave up on the antibiotics after 3 months and prescribed an antiviral instead. When I decided to try herbs on my own, the same happened but not to quite the same extent.

I hit the wall with HBOT as well.

I tested negative for the mthfr mutation.

Am I overlosded with toxins?

I have an appt in September in D.C. but am afraid I’ll have the same issues.


I’ve been taking 250000 units of. Nystatin every other day and 1 desbio pathoguard which is making me Herx.

Additionally my vision is so bad it dims, it has fogged over and the light from my iPad is blinding.

Any advice is greatly appreciated.
My best to each of you. Xoxo

Look into mast cell issues

Hi MargaritaLyme

Make sure you emphasize your history of sensitivity to the abx at your appt.
You mentioned an appt in DC.
If it’s at the J clinic - they will put you in a pulsed protocol - so not taking abx every day.
But - you will likely be prescribed 3 abx at one time - or two abx plus an antimalarial.

Please Let us know how your appt goes.

MargaritaLyme,

Welcome! If you are very toxic and sensitive, you likely have mold exposure (past or present) and/or heavy metal toxicity.

I would consider doing a MycoTox test for mold toxins (Great Plains Lab or Realtime Labs). If positive, you need to test your environment (ERMI or HERTSMI-2) and/or hire a qualified professional to inspect and test for mold. ERMI/HERTSMI-2 is more relevant for us, as mold inspectors do not view mold as harmful as it really is and they use mainly air samples which don’t give as thorough a view of what is actually in the house/building. You would need to evaluate home and workplace to identify where the exposure is occurring and either remediate or relocate to a clean building. Water damaged buildings have mold. If you know there’s been water damage, you know there’s mold. No need to test then unless you are going to try to remediate.

The Andy Cutler Facebook group has information about heavy metal testing. If you have amalgams in your teeth, that is the usual source of mercury although there are other sources. Amalgams should only be removed safely. Look for a biological dentist who is SMART certified or follows those guidelines and uses those methods. The IAOMT website has everything you need to know and how to find a dentist.

Parasites can be an issue as well. Parasites can be closely connected to heavy metal toxicity. If you suspect parasites, you may want to do something to address that before aggressive abx. Dental cavitations and root canals can be sources of infection that can make it difficult to get rid of parasites. A cavitat or cone beam scan reviewed by a biological dentist can identify these issues.

Just some ideas of things that make it hard for people to tolerate treatment.

Post Edited (WalkingbyFaith) : 8/18/2019 7:41:04 AM (GMT-6)

Echoing others, I'd look into MCAS. I have MCAS issues related to die-off symptoms, whenever I treat with effective antimicrobials my flares are beyond all proportion. What I think is happening is I have immune hypersensitivity to the pathogen toxins, so whenever die-off is created the immune system has a hair trigger response that causes a full on cascade which amplifies the die-off symptoms.

I've found integrating combo antihistamines to be helpful when I'm treating the infections. Currently on zyrtec, zantac, ketotifen, singulair. A lot of people do well with quercetin. Some also take cromolyn.

I interpreted the fact that the anthistamines helped manage the severity of my flare responses as confirmation that some type of MCAS issue was likely playing a role.

Thank you so much for all your input. I do suspect mast cell issues as a test (by a different doctor) revealed my histamines were elevated. Is one Claritin per day enough. My nose has been running constantly and I have food sensitivities.

I have had to switch docs out of necessity. I reside in MI and there aren’t many choices. My appt is at Dr. Js Clinic with one of his PAs. I will definitely mention my sensitivity to antibiotics.

How much detoxing should I be doing? Activated charcoal twice daily? Lemon water all day? Epsom salt foot bath once daily?

Many Thanks for your help. I have been housebound for a very long time only venturing out for treatments. I also have Hashimoto’s which I suspect is playing a role.

Thank you again Girlie and everyone. I so appreciate the help.

I will definitely try the Claritin/Zyrtec and Pepcid. Is testing for histamines inaccurate? By triggers do you mean certain foods?