Disulfiram - Part 6

JovaLyme said...


Interesting thoughts as ever Quin.

I'm noticing Disulfiram having less and less effect on me too. I've taken 250mg today with no problem at all.

I hear what you are saying about the farts! Sweet Jesus, they are bad on this stuff!

When I took Disulfiram 2 years ago or so, I took up to 500mg a day with not much reaction at all, some minor herxing.

Understand that these coinfections can lay dormant, hide deep within the body, then once you wake them up and the killing starts to happen, the cytokine response comes, that's when you start to feel the severe herxing and feel like you're dieing. It'll take time, but you'll get to the point where you're feeling the severe herxes Jova Lyme. Just be careful, as sometimes the herx will come out of the blue and wake you up right out of your sleep, then put you in the ER. Been there done that, lol, as many lyme patients have.

It took me to fully knock down babesia with primaquine and coartem, then 3-4 months of CSA Formula and A-bab to finally bring out Bartonella. And that's when I finally became super sensitive to herbs like oregano with my bartonella antibiotics like bactrim and biaxin.

And once Bartonella is out, it's out for good, and a b!tch to put back into remission.

Dr Kinderlehrer said some Doctors are using triple antibiotic protocols to put Bartonella back into remission and he thinks Bartonella is the "most difficult to treat!"
https://youtu.be/q6dlpvbuxrq?t=1095

Interesting considering someone on the Beating Bartonella group a week ago chimed in saying Cowden claims "you can beat Bart in 4-8 weeks with his protocol."

I loved watching the comments role in after that one, I'm grateful to see that the Facebook community has more realistic views on treating these coinfections, maybe because they're real identity is shown...

Anyways, I think the Dr Kinderlehrer protocol he's using of using Rifampin with super low dosage of 62.5 mg of DSF in an ingenious protocol, I could see that working really well for bartonella. But I still suspect the herxing may be too severe to tolerate after a few weeks, gotta back off when this starts happening.

🔹RainyCloud said...
Girlie the password is: girlie

All lower case.

I just read this now... will go check my emails in s bit

JovaLyme said...
I feel worse than when I started Girlie, that's the problem.

I wouldn't describe the feeling as herxing either. It feels like it is just aggravating my neuro symptoms and making them worse. I feel very inflamed as it is and this really isn't helping.

It's probably making the bartonella worse. You really need to be taking doxycycline with it (or minocycline or methylene blue).

I got a pretty intense herx for the first week or so, but now I'm not getting as much. It's not completely gone though. The disulfiram easily killed all the bacteria that were exposed, but there's still some hiding.

I'm probably going to do another round of depakote instead. I can generally tolerate that for the 2 to 3 weeks that it takes to penetrate the cysts and kill the bacteria. I really don't like the manic-depressive effect of the disulfiram. Valproate just makes me tired and suppresses REM sleep a bit.

potsnpans said...
For me it was "manic" shortly after dosing. Same for you?

Yes

Hi yesterday I started week 4 of Disufliram.

Last week I was having on-again-off-again difficulties. Two things, I took black seed oil which I think made me feel horrible. I will no longer take black seed oil and DSF. Second, Turmeric really knocked down the inflammation. So well, I was able to up the dosage in a few days.

I am at 120mg daily and getting herx hangovers in the morning. But not to harsh to wreck my day. Waking up, taking Alka Seltzer Gold and moving around is all I need to get out of it. I will continue to take 120mg for one to three weeks until I no longer get herx. Then I will increase it to 250mg.

Disulfiram does not lose it's effectiveness at low doses. This is not a true statement. You have to wait until you reach the load up dosage which is its half life plus two or three days, which is 5-7 days. I have extended that to 2-3 weeks because I need to be functional for work.

Again, Turmeric really helps with the inflammation. Magnesium, Zinc, Potassium, Iodine, Selenium, Alka Seltzer Gold (Citric acid, sodium, potassium), and fasting every few days is working for me.

I have a flare up of some kind of co-infection which is appearing on my skin around my head. I have been effective at knocking it down. I use Oregano Oil mixed with Vick's Vapor Rub(Camphor, Eucalyptus Oil, Methenol), Epson Salt Showers, and 1/2 tea spoon Ivermectin 5mg cow wash seems to hold it back. I am go to order higher quality essential oils and ditch the vick's vapor rub because it is probably chemical turpenines and I want organic. This with clove tea and Methylene Blue, Quinine in low dosages. I have had more good days then bad in the last week.

After 5 days 20% remains in your body. So only doing something for a few days does not allow it to build up.

I think the post about turmeric is important.

Maybe it's important to focus on lowering the inflammation as much as possible.

I haven't taken any disulfiram for 5 days, and I'm still herxing from it. Wow, it takes a long time for the bacteria to die.

yeah in a previous thread I mentioned I had a series of major herxs 2.5 weeks later.

what I don't want is to have a delayed herx on top of a new one

so far, I think it comes down to these variables
* load up: DSF half life is 5 days, meaning it takes 5-7 days to "get up" to the dosage
* delayed die off: it will kill things immediately in the blood stream, but also it appears to hit the reproductive cycle stronger. And depending on what life cycle the lyme was at this can be 7-28 days until the reproduce and then die. This is the delay.
* amplification effect: it appears to hit inside cysts. However, the concentration of DSF around the cyst might not be enough to kill those specific bacteria in or around that cyst in entirity. The cyst breaks open and overwelms the DSF concentration. But then once open, it moves around in the body where it dies off. So you get a 2x kill or "amplified" effect. Pure speculation. But I had a neuropathy attack, my brain "told me" this while showing a picture of them splinting open. I know weird right? Not saying its the aliens but its the aliens moment.

And then you have the co-infection getting stirred up, which for me, appears on the skin. I've been doing great with Ivermectin Cow wash (again, weird), Vick's vapor rub, one or two Amoxicilians here or there, and Oregano Oil.

Another note, blackseed oil and green tea made me HORRENDOUSLY sick.

Girlie said...
Continued herxing - maybe you’ve got a lot of toxins built up - and you may not be killing anything now. But toxins from dieoff a few days ago

My shoulder hurts, there's clearly some dead bacteria in there. Perhaps the bacteria were already dead, and it just took this long for the biofilm to dissolve.

I was herxing a month after I took valproate... it can last a long time.

I never got this kind of prolonged herx from beta-lactams or tetracyclines or macrolides. It lasts a few days at most.

What exactly does the green tea reaction feel like? I had Chinese food yesterday, and didn't notice anything. I'm herxing, but I was herxing before.