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what is the exact procedure when testing out antibiotics

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Posted 1/11/2020 4:07 PM (GMT 0)
I am wondering about if anyone have knowledge what is the exact procedure when testing out antibiotics. My thinking is logically the test would be to first separate the bacteria/spirochete to a group or culture and so it can be studied under microscope and one can see them happy and thriving. Then when adding the antibiotics the happy thriving would soon turn into a calamity for them little buggers, and finally wipe out the entire colony in a certain amount of time. And the better the antibiotics the quicker wiping i suppose.. Would I be right…is this about the approximate procedure for developing new antibiotics…..?
My other wondering would then be, if there is any available data/link when there is tested out the antibiotics for killing lyme that one can study. For using Doxycycline as an example, any available data to read how long time under a microscope until the spirochetes are killed, efficiency compared to other antibiotics etcetera. Surely there must be a study of this kind somewhere to see how efficient different lyme-antibiotics are…?
Posted 1/11/2020 6:23 PM (GMT 0)
Hey MooseSafari! Good info available in Stephen Buhner's book, "Healing Lyme." It's never as simple as you describe, unfortunately. Borrelia spirochetes are tiny, and unless the infection is treated immediately with long-term Doxycycline, you won't kill it. When the Borrelia is under attack it very quickly starts forming encysted ("Round-Body") forms, which Doxycycline is mostly ineffective at killing. The "Round-Body" forms can become reactivated and morph back into the spirochete form. It's a creepy-smart bacteria.
Posted 1/11/2020 6:25 PM (GMT 0)
https://www.ncbi.nlm.nih.gov/pmc/articles/pmc4827596/
Posted 1/11/2020 6:49 PM (GMT 0)
Lyme also can morph into a cell wall-deficient form when threatened, and because many abx work by bursting the cell wall, this form is not killed by those abx. So sneaky.

Additionally, after the first few weeks, Lyme is not just hanging out in your bloodstream. It can be in your brain, tissues, organs, etc. Various antimicrobial treatments are better at reaching those places than others because they are not accessed the same way. This is why some of the stevia hoopla died down - yes, stevia is a great Borrelia killer in a test tube, but it doesn't penetrate the intestinal wall, so it might only kill Lyme in the GI tract.

So it's complicated, especially with Lyme that can be intracellular, dormant cysts, spirochetes, cell wall-deficient.... Really, all due respect to the crafty Borrelia.

But I hear you, it's nice to know what's going on at a micro level.
Posted 1/12/2020 12:13 PM (GMT 0)
Thanks, great answers here as always, I couldnt imagine a more well-educated group of great folks than here...

Its right now i am in the agony of deciding weather i should take the final step and start taking antibiotics. Its not so easy to choose.
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