Canfossi said...
How many people have been on Disulfiram and do you find that it has helped a lot? I understand it is for persistent Lyme also kills babesia too? Thanks!
Definitely hits babesia and borrelia hard, also strong enough to hold bartonella all on it's own even at 62.5mg once daily from my experience, but is it capable of putting all three in remission? Here's the thing, with time it may be possible considering it doesn't kill of any microbiome, which could possibly take you out of that autoimmune state and heal an imbalanced microbiome, thus which in the long run strengthen your immune system and make treating something like bartonella a lot easier.
We're still discovering new things about
imbalanced microbiome, mast cell activation disorder, etc... How they all play a role with keeping a lot of these diseases chronic.
I think Dr. Tania Dempsey said it best on this Better Health Guy podcast, that the biggest obstacles to treat seem to be the drug resistance coinfections, and like she said, these coinfections shouldnt be called coinfections considering they seem to be the primary infections, meanwhile borrelia lurking in the background. I suspect biofilms also play a role, keeping both babesia and bartonella in the biofilm sludge protecting them. It seems as once you knock one back, the other one sprouts up again, this biofilm may play a role in that as it seems to be like a whack-a-mole game.
https://youtu.be/937szjdnvgwMy opinion is you'll find better answers and more recent information on what you're looking for on Disulfiram at the Group on Facebook
https://www.facebook.com/groups/dsf4lyme/I don't quite understand how things get discombobulated on the forums with numerous members saying Disulfiram doesn't treat Bartonella, when one of the top LLMDs that treats with this drugs claims it does hit Bartonella, Dr. L - ""Disulfiram does hit bartonella."
https://youtu.be/q6dlpvbuxrq?t=292Along with Dr. Rajadas saying recently in a video that his colleague believes it kills bartonella. All the information is leading to it hitting bartonella at some point. Misconceptions happen when lyme patients just keep repeating on the forums it just flares their bartonella symptoms. Again, define flaring, what does that mean? I guess some people believe it means it isn't killing the bartonella bacteria, while they believe that, where they heard that, I haven't a clue. My bartonella symptoms flared for the first few days, then they died down.
The problem is also that some are an earlier stage with chronic lyme disease, while some of us are closer into remission. Some also haven't changed their diet around too, they should be on a low carb diet when treating with disufliram. As I noticed if I stay eating carbs or sugar while on Disulfiram bartonella just flares for me, I think this goes back to this article and how sugar brings out the bacteria into feeding phase, the herxing it just to severe to tolerate with disufiram. And some just go hog wild with starting out to high of dosage, not allowing their body to deal with the herxing die off load from the toxins.
"Sugar Helps Antibiotics Trick and Kill Deadly Bacteria"
https://www.livescience.com/14124-sugar-improves-antibiotic-treatment-persistent-bacterial-infections.html
Bottom line, it's nice to hear that majority are tolerating it well and experiencing less severe side effects compared to the quinines that treat babesia/malaria along with the fluorquinolenes that treat bartonella, both of these drugs are very unsafe to take longterm. Quines can cause damage to the brain stem(quinism), which for some can become permanent. And I've heard fluoroquinolones can also cause permanent neuropathy damage for some, some have even reported permanent anxiety and depression disorders as well. I took primaquine and had a brief bought of psychosis, before it was known that Disulfiram effectively targets babesia. Which I knew what I know now. I'll never take a quinine again, that psychosis I developed was very scary. It's common in the military of soldiers losing their mind out on the war field just being on an antiparasitic drug like mefloquine for too long.
The new thing now that's talked about
on the Facebook group is that Disulfiram causing withdrawal side effects, despite all these years no reports by alcohol patients. I have yet to hear Dr. K and Dr. L report on anything like this, but some believe that once your body fully clears on the 14th day, even just getting off the drug, some are having severe psyche symptoms. Take everything with a grain a salt. Problem is, yes too much dopamine can possibly build up in the brain cause side effects, even when getting off. I'm sure, but problem is these hallucinating, depression, and anxiety are all caused by bartonella too. And as I noticed, once you wake up bartonella with a drug like Disulfiram, it's like having a genie out of the bottle forever which I think many are failing to realize.
In all the 9 - 10 years dealing with this lyme disease, my PANS and Bartonella psych symptoms really didn't start flaring until I started treating with these more aggressive persister cell drugs on the 9th year. When I first tried Disulfiram, I was getting all these weird OCD symptoms that came out of nowhere including intrusive thoughts. What I'm getting at is, some of these infections like bartonella will stay dormant and it isn't until you start hitting them hard with the right drug, it wakes them up and they start to show their true face.
So what I'm getting at is, I think just like what I went through, many of other lyme patients are experiencing and don't understand it. While some of these lyme patients are convinced they're suffering from the side effects of the drug disulfiram, they may be suffering from herxing and even suffering repercussions of waking up this dormant infection, then letting wreak havoc on their brain because they're now off the drug because they think it was the drug, not the lyme infection. Be aware there's just traditional people with healthy immune systems that wake bartonella up in their body by just a recent car accident, even just by taking an antibiotic, then later end up in the psych ward not knowing what's causing all their psychological problems. Yes this is what you're dealing with and how sinister the bacteria is. Listen to what Dr. Hirsch had said about
bart on Better Health guy's podcast
https://youtu.be/tgjjtdapfdi?t=578My personal feeling is, I'll deal with the pain and fatigue any day out of the weak from borrelia and babesia. I've dealt with all three, the first two years were hard when I was fully disabled a decade ago from arthritis and inflamation, but now that seems like childs play after dealing with bartonella.
There's some boasting on here that Disulfiram also claims it's still unsafe to take, yes I think it may cause some side effects like psychosis if ramped up to fast due to die, possibly psychosis also from built up dopamine it causes. But I took it for 2 1/2 months straight, reducing a lot of my PANS symptoms that a lot of the standard antibiotics like rifampin, bactrim, omnicef, just couldn't touch and were failing to do. There's two things I suspect that these standard bartonella antibiotics aren't doing such as penetration, absorbing into the body as much as disulfiram, crossing the blood brain barrier, along hitting the borrelia and bartonella persister cells, which disulfiram has already shown to target borrelia persister cells in vitro.
Anways, don't be afraid to use the search box on here and see what many peoples experiences are with this drug, but honestly I seem to be finding a lot better experiences on the Dislfiram facebook group, probably due to that group being solely devoted to the drug. There's one patient that recently reported as if all his bartonella PANS symptoms melted away while being on Disulfiram for only 3 months, he said he still had ways to go treating, but he said he feels incredibly better.
No doubt Disulfiram is a huge breakthrough for chronic lyme, but I suspect this is going to help a lot of other patients dealing with other diseases like cancer and even drug resistant bacterial infections, like this article is hinting too.
"Likewise, the study will test disulfiram-vancomycin combination treatments in a vancomycin-intermediate resistant Staphylococcus aureus infection model."
https://www.eurekalert.org/pub_releases/2020-02/mujc-mus022720.php Anyone aware that disulfiram can inhibit SARS and MERS, both forms of corona virus
"Disulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes"
https://www.ncbi.nlm.nih.gov/pubmed/29289665It's incredible we've been sitting on this drug for decades, not knowing this drug could help millions, even cancer patients.
https://www.ncbi.nlm.nih.gov/pubmed/31084595As Dr. Rajadas said, this drug may win the molecule of the year award.
Another one to watch is fenbendazole, which a lot of glioblastoma are trying after one cancer patient had success using cbd with that antiparasitic deeworming drug for dugs.
I know a leading LLMD in Washington uses that on her patients with Morgellons, which supposedly there's a link between Morgellons and Lyme believe it or not...