COVID-19 GH Style

It has taken a lot of time but I am finally ready to post my theory on what COVID-19 is doing to patients. In a nutshell, the virus is causing our blood to not carry oxygen very well. It is my belief that the virus has an 32 kda terminal protein that directly mimics carbonic anhydrase II. It binds the CO2 on hemoglobin and causes the release of heme iron. Without heme iron, the hemoglobin can not carry as much oxygen and the immune system must get rid of the free heme iron. Heme iron is toxic and so much gets released that it overwhelms the immune system. This causes their lungs to fill with fluid. These patients do not have ARDS and do not need ventilators, they need new blood and preferably blood from previous COViD patients because it will have antibodies against the virus. Unless we reduce viral load, if a patient gets in poor condition, it will be difficult to over come their problems.

Hydroxychloroquine, Azithromycin, zinc, and Vitamin C can all be beneficial if used early in the process. They won't make much difference if given later in the process. I will be interested to see if a medication like Acetazolamide would be of benefit in this situation. Theoretically, it could be help.

My recommendation for an active COVID patient would be 1000 mg of Liposomal Vitamin C every 15 to 30 minutes for a total daily dose of 25,000 mg per day for 2 days or symptoms subside. If it causes GI side effects, back off the dosage slightly. Vitamin C is limited in its absorption to 400 to 500 mg every 15 to 30 minutes. Taking high doses without multiple frequent dosing is counterproductive and the liposomal form has much better absorption.

Basically, I just spent 2 weeks researching for those 3 paragraphs. I hope it doesn't take the scientists that long to tell the doctors so we can save more people.

My 2 sources of Vit C that I have been using regularly are unavailable now. I do have some Bulk Supplements powdered C on hand. Is there a way to make it liposomal? If so, how?

i dont think theres a way to make it liposomal. i like quicksilver vit c still on amazon

dcd, Vitamin C does many things that will help but the main two are increase the immune response to prevent viral replication and as an anti-oxidant, it can reduce the heme iron that is causing the problem.

Regular vitamin c rips my gut up. So thats one suppliment I never really looed into further. I know there are many C types, never seen this liposomal C before.

Yep, they're doing blood trans from the covid19 healed with success on the sick ones.

Being a lymie, blood transfusion sounds like it can cause other issues.

I hesitate to post this video but I can't help myself! I find it fascinating.
have been reading this exact theory and related thoughts the last few days, it does seem to be getting out there a little, hopefully more will come of it quickly, like you said Georgia. So this is a really interesting video I cam across last night. It has interesting vitamin C information and plenty more. Obviously I cannot speak to the validity of anything he says but much falls in line with the other info I have come across.

https://www.youtube.com/watch?v=fw4CcQg_1z4

So Georgia, this doesn't cause acute respiratory distress syndrome (ARDS), but it does cause the massive build up of fluid in the lungs? Can you explain why the immune system would end up flooding the lungs due to high levels of iron in the blood?

This is definitely interesting and I'd like to pursue it further... can we be sure that the virus attacks red blood cells in this way? The only article I've been able to find supporting this is a preprint (not peer reviewed) of a computational model (neither in vivo, nor in vivo):
https://chemrxiv.org/articles/covid-19_disease_orf8_and_surface_glycoprotein_inhibit_heme_metabolism_by_binding_to_porphyrin/11938173/5

I was also able to find this about an AI tool that predicts ARDS in infected patients (note: they define ARDS as synonymous with fluid in the lungs)
https://www.nyu.edu/about/news-publications/news/2020/march/experimental-ai-tool-predicts-which-patients-with-pandemic-virus.html
The tool says that during infection, 80% of those with low hemoglobin, high ALT, and reported body aches are getting ARDS. Would the excess iron be the cause of elevated ALT? If so that would seem to further buttress the idea.
Can you point me towards any other articles?

One more question
You said "Taking high doses (of vitamin c) without multiple frequent dosing is counterproductive..."
Why "counterproductive" and not simply "unproductive"?

Lymie24 said...
So are ventilators pointless?

I think you know the answer. With the way modern medicine works (in this case taking too long, with wrong approach)....no they are not pointless.

If medicine did this right from the start, then there would be way less ventilator demand thats for sure.

Tire plugs would be pointless too if drivers could all avoid road debris. Sharp metal pointy objects seem to be attracted to any tires I have.

Yeah, pointless was bad terminology. According to JAMA Internal Medicine more than 40% of individuals in the study hospitalized for severe and critical COVID-19 developed ARDS—and over 50% of those diagnosed died from the disease.

A lot to try to answer, but to potsnpans, I found the preprinted abstract you linked after I had formulated my theory. It supports what I believe is happening. ARDS is a respiratory failure characterized by widespread inflammation of the lungs. The patients definitely have the inflammation, but ARDS impairs the exchange of CO2 and O2 in the blood. The lungs can't move enough to make it happen and a ventilator helps the lungs move to do give the patient more air. But in COVID patients, the impairment of CO2 and O2 exchange is what causes the ARDS. Its backwards. Ventilators only breathe for you, they don't improve the gas exchange in the lungs. That is why the death rate is so high for patients on the ventilators that have COVID. The liver does all it can to reduce the increased oxidative stress from the increase in heme but because hypoxia has set in, it can't function properly and ALT increases. As for references, I think I have 13 on this computer but I probably have that many on my work computer as well. It took a lot of time as I was looking in out of the way pathways. For instance, this isn't on too many people's radar. https://portlandpress.com/biochemj/article-abstract/407/1/61/41930 This shows that carbonic anhydrase inside RBC's have a 32 kda sequence homology that can be mimicked by a virus. If you read about carbonic anhydrase, you will see it is responsible CO2 and fluid regulation are what it is does in the lungs. That is the problem these patients are having. https://febs.onlinelibrary.wiley.com/doi/full/10.1111/j.1432-1033.1981.tb05697.x It literally takes 15 to 20 seconds to scroll through folders just to get to the folder on COVID and then I have to read through those. I didn't post references because things like https://www.jbc.org/content/259/4/2570.short really don't help most people but it helps me see how things work.
As for ventilators, they are better than nothing but we need to change the way we are treating this because they aren't improving oxygen levels. Max oxygen from the start (what they did for England's Prime Minister) and immune supportive measures while reducing viral load would be my preferred treatment.

I don't think it's about getting max oxygen from the start, it's about not letting the virus get settled into the epithelium of our airway. Keeping our immune system functioning as high as possible is paramount and Lymies aren't known for robust immune systems. Years of inflammation have causes so many nutritional deficiencies that it would make if difficult. My recommendation of liposomal Vitamin C every 15 minutes still stands and would be the best thing one could do to prevent a disseminated virus.

The immune system's job is to decrease the amount of charged particles in the blood. Heme iron is a charged particle. Vitamin C can actually remove 2 charged particles instead of one like most agents. SOD is the best at removing 3 charged particles but many of us have decreased SOD levels due to epigenetic shifts.

Ventilators are causing harm to some as the pressure damages the soft tissue of the lungs. It's about a wash between the good they do and the damage they do.

I have recommended high doses of Vitamin C since this entire thing started.

Just saw this from Stephen Buhner:

"As usual with emerging situations, there are a great many speculations occurring among researchers, some of which will be accurate, some not. however, just in case the emerging speculation re: the covid-19 virus attacking red blood cells is accurate . . . Sida acuta is a red blood cell protector and regenerator, in essence a red blood cell adaptogen. It is common in florida and along the gulf coast so it is pretty widely available. Should the speculation be accurate, I would just add it to any herbal protocol you might be using for the coronavirus, perhaps 1/2 tsp 3-6x daily. If it turns out to be VERY helpful, i would double that dose for active infections."

Also should note in his original protocol for Covid-19 he uses rhodiola to protect against hypoxia...
https://www.stephenharrodbuhner.com/wp-content/uploads/2020/03/coronavirus.txt.pdf